New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.
dc.contributor.author | Zhu, Weixing | |
dc.contributor.author | Haupenthal, Jörg | |
dc.contributor.author | Groh, Matthias | |
dc.contributor.author | Fountain, Michelle | |
dc.contributor.author | Hartmann, Rolf W | |
dc.date.accessioned | 2014-09-16T12:41:07Z | |
dc.date.available | 2014-09-16T12:41:07Z | |
dc.date.issued | 2014-07 | |
dc.identifier.citation | New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent. 2014, 58 (7):4242-5 Antimicrob. Agents Chemother. | en |
dc.identifier.issn | 1098-6596 | |
dc.identifier.pmid | 24820077 | |
dc.identifier.doi | 10.1128/AAC.02600-14 | |
dc.identifier.uri | http://hdl.handle.net/10033/326174 | |
dc.description.abstract | CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to Antimicrobial agents and chemotherapy | en |
dc.title | New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent. | en |
dc.type | Article | en |
dc.identifier.journal | Antimicrobial agents and chemotherapy | en |
refterms.dateFOA | 2018-06-12T22:50:31Z | |
html.description.abstract | CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents. |