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dc.contributor.authorZhu, Weixing
dc.contributor.authorHaupenthal, Jörg
dc.contributor.authorGroh, Matthias
dc.contributor.authorFountain, Michelle
dc.contributor.authorHartmann, Rolf W
dc.date.accessioned2014-09-16T12:41:07Z
dc.date.available2014-09-16T12:41:07Z
dc.date.issued2014-07
dc.identifier.citationNew insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent. 2014, 58 (7):4242-5 Antimicrob. Agents Chemother.en
dc.identifier.issn1098-6596
dc.identifier.pmid24820077
dc.identifier.doi10.1128/AAC.02600-14
dc.identifier.urihttp://hdl.handle.net/10033/326174
dc.description.abstractCBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents.
dc.language.isoenen
dc.rightsArchived with thanks to Antimicrobial agents and chemotherapyen
dc.titleNew insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.en
dc.typeArticleen
dc.identifier.journalAntimicrobial agents and chemotherapyen
refterms.dateFOA2018-06-12T22:50:31Z
html.description.abstractCBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents.


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