TCR-triggered extracellular superoxide production is not required for T-cell activation.
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Issue Date
2014
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In the last decade, reactive oxygen species (ROS) production has been shown to occur upon T-cell receptor (TCR) stimulation and to affect TCR-mediated signalling. However, the exact reactive species that are produced, how ROS are generated and their requirement for T-cell activation, proliferation or cytokine production remain unclear, especially in the case of primary human T cells. Moreover, several groups have questioned that ROS are produced upon TCR stimulation.Citation
TCR-triggered extracellular superoxide production is not required for T-cell activation. 2014, 12:50 Cell Commun. SignalPubMed ID
25081034Type
ArticleLanguage
enISSN
1478-811Xae974a485f413a2113503eed53cd6c53
10.1186/s12964-014-0050-1
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