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dc.contributor.authorBlankenfeldt, Wulf
dc.contributor.authorParsons, James F
dc.date.accessioned2014-12-10T15:09:03Zen
dc.date.available2014-12-10T15:09:03Zen
dc.date.issued2014-09-09en
dc.identifier.citationThe structural biology of phenazine biosynthesis. 2014, 29C:26-33 Curr. Opin. Struct. Biol.en
dc.identifier.issn1879-033Xen
dc.identifier.pmid25215885en
dc.identifier.doi10.1016/j.sbi.2014.08.013en
dc.identifier.urihttp://hdl.handle.net/10033/337028en
dc.description.abstractThe phenazines are a class of over 150 nitrogen-containing aromatic compounds of bacterial and archeal origin. Their redox properties not only explain their activity as broad-specificity antibiotics and virulence factors but also enable them to function as respiratory pigments, thus extending their importance to the primary metabolism of phenazine-producing species. Despite their discovery in the mid-19th century, the molecular mechanisms behind their biosynthesis have only been unraveled in the last decade. Here, we review the contribution of structural biology that has led to our current understanding of phenazine biosynthesis.
dc.languageENGen
dc.titleThe structural biology of phenazine biosynthesis.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for Infection Research, Structure and Function of Proteins, Inhoffenstr. 7, 38124 Braunschweig, Germany. Electronic address: wulf.blankenfeldt@helmholtz-hzi.de.en
dc.identifier.journalCurrent opinion in structural biologyen
refterms.dateFOA2018-06-13T09:23:23Z
html.description.abstractThe phenazines are a class of over 150 nitrogen-containing aromatic compounds of bacterial and archeal origin. Their redox properties not only explain their activity as broad-specificity antibiotics and virulence factors but also enable them to function as respiratory pigments, thus extending their importance to the primary metabolism of phenazine-producing species. Despite their discovery in the mid-19th century, the molecular mechanisms behind their biosynthesis have only been unraveled in the last decade. Here, we review the contribution of structural biology that has led to our current understanding of phenazine biosynthesis.


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