Submicron polymeric particles prepared by vibrational spray-drying: Semisolid formulation and skin penetration/permeation studies.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractTopical glucocorticoids (TG) such as dexamethasone (DEX) have been used for decades for the treatment of skin diseases. However, TG present well-documented side effects and their delivery to the skin is often insufficient. Therefore, many efforts have been undergone to improve the amount of drug delivered to the skin and to reduce side effects at the same time. In this work, the feasibility of DEX-submicron polymeric particles (SP) prepared by vibrational spray-drying as an approach to overcome the challenges associated with the topical administration of this drug class was evaluated. DEX was homogeneously dispersed in the SP matrix, according to confocal Raman microscopy analysis. Drug-loaded SP were incorporated into the oil phase of oil-in-water emulsions (creams). The formulation containing polymeric submicron particles (C-SP) showed controlled drug release kinetics and a significant drug accumulation in skin compared to formulations containing non-polymeric particles or free drug. DEX accumulation in the stratum corneum was evaluated by tape stripping and a depot effect over time was observed for C-SP, while the formulation containing the free drug showed a decrease over time. Similarly, C-SP presented higher drug retention in epidermis and dermis in skin penetration studies performed on pig skin in Franz diffusion cells, while drug permeation into the receptor compartment was negligible. It was demonstrated, for the first time, the advantageous application of submicron polymeric particles obtained by vibrational spray-drying in semisolid formulations for cutaneous administration to overcome challenges related to the therapy with TG such as DEX.
CitationSubmicron polymeric particles prepared by vibrational spray-drying: Semisolid formulation and skin penetration/permeation studies. 2014, 88 (3):602-13 Eur J Pharm Biopharm
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
JournalEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
The following license files are associated with this item:
- Topical delivery of lipophilic drugs from o/w Pickering emulsions.
- Authors: Frelichowska J, Bolzinger MA, Pelletier J, Valour JP, Chevalier Y
- Issue date: 2009 Apr 17
- Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers.
- Authors: Döge N, Hönzke S, Schumacher F, Balzus B, Colombo M, Hadam S, Rancan F, Blume-Peytavi U, Schäfer-Korting M, Schindler A, Rühl E, Skov PS, Church MK, Hedtrich S, Kleuser B, Bodmeier R, Vogt A
- Issue date: 2016 Nov 28
- Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and laser scanning microscopy.
- Authors: Lohan SB, Saeidpour S, Solik A, Schanzer S, Richter H, Dong P, Darvin ME, Bodmeier R, Patzelt A, Zoubari G, Unbehauen M, Haag R, Lademann J, Teutloff C, Bittl R, Meinke MC
- Issue date: 2017 Jul
- Topical drug delivery by a polymeric nanosphere gel: Formulation optimization and in vitro and in vivo skin distribution studies.
- Authors: Batheja P, Sheihet L, Kohn J, Singer AJ, Michniak-Kohn B
- Issue date: 2011 Jan 20
- Development of ciclopirox olamine topical formulations: evaluation of drug release, penetration and cutaneous retention.
- Authors: Pinheiro VA, Serikaku D, Baby AR, Velasco MV, Kaneko TM, Consiglieri VO
- Issue date: 2015 Mar