Murine solid tumours as a novel model to study bacterial biofilm formation in vivo.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Pawar, VCrull, K
Komor, U
Kasnitz, N
Frahm, M
Kocijancic, D
Westphal, K
Leschner, S
Wolf, K
Loessner, H
Rohde, Manfred
Häussler, S
Weiss, S
Issue Date
2014-08
Metadata
Show full item recordAbstract
Bacteria of many species are able to invade and colonize solid tumours in mice. We have focused on Salmonella enterica serovar Typhimurium. Detailed analysis revealed that such tumour-invading Salmonella form biofilms, thus providing a versatile in vivo test system for studying bacterial phenotypes and host-pathogen interactions. It appears that biofilm formation by S. typhimurium is induced as a defence against the immune system of the host, and in particular against neutrophils. Further, we extended our work to the clinically more relevant biofilm infection by Pseudomonas aeruginosa. The induction of P. aeruginosa biofilms in neoplastic tissue appears to be elicited as a reaction against the immune system. Reconstitution experiments reveal that T cells are responsible for biofilm induction. Isogenic mutants that are no longer able to form biofilms can be used for comparison studies to determine antimicrobial resistance, especially therapeutic efficacy against P. aeruginosa located in biofilms.Citation
Murine solid tumours as a novel model to study bacterial biofilm formation in vivo. 2014, 276 (2):130-9 J. Intern. Med.Affiliation
Helmholtz Centre for infection research, Inhoffenstr.7, 38124 Braunschweig, Germany.Journal
Journal of internal medicinePubMed ID
24724621Type
ArticleLanguage
enISSN
1365-2796ae974a485f413a2113503eed53cd6c53
10.1111/joim.12258
Scopus Count
The following license files are associated with this item:
Related articles
- Biofilm formation by Salmonella enterica serovar Typhimurium colonizing solid tumours.
- Authors: Crull K, Rohde M, Westphal K, Loessner H, Wolf K, Felipe-López A, Hensel M, Weiss S
- Issue date: 2011 Aug
- Biofilm formation by Pseudomonas aeruginosa in solid murine tumors - a novel model system.
- Authors: Komor U, Bielecki P, Loessner H, Rohde M, Wolf K, Westphal K, Weiss S, Häussler S
- Issue date: 2012 Sep
- Use of bacterial culture supernatants as anti-biofilm agents against Pseudomonas aeruginosa and Klebsiella pneumoniae.
- Authors: Alghofaili F
- Issue date: 2022 Feb
- Characterization of biofilm-forming abilities of antibiotic-resistant Salmonella typhimurium DT104 on hydrophobic abiotic surfaces.
- Authors: Ngwai YB, Adachi Y, Ogawa Y, Hara H
- Issue date: 2006 Aug
- Biofilm formation in field strains of Salmonella enterica serovar Typhimurium: identification of a new colony morphology type and the role of SGI1 in biofilm formation.
- Authors: Malcova M, Hradecka H, Karpiskova R, Rychlik I
- Issue date: 2008 Jun 22