Show simple item record

dc.contributor.authorLadwein, Markus
dc.contributor.authorRottner, Klemens
dc.date.accessioned2008-08-29T08:49:47Z
dc.date.available2008-08-29T08:49:47Z
dc.date.issued2008-06-18
dc.identifier.citationOn the Rho'd: the regulation of membrane protrusions by Rho-GTPases. 2008, 582 (14):2066-74 FEBS Lett.en
dc.identifier.issn0014-5793
dc.identifier.pmid18442478
dc.identifier.doi10.1016/j.febslet.2008.04.033
dc.identifier.urihttp://hdl.handle.net/10033/36812
dc.description.abstractCell migration entails the formation of cellular protrusions such as lamellipodia or filopodia, the growth of which is powered by the polymerisation of actin filaments abutting the plasma membrane. Specific Rho-GTPase subfamilies are able to drive different types of protrusions. However, significant crosstalk between Rho-family members and the interplay of distinct Rho-effectors regulating or modulating actin reorganization in protrusions complicate the picture of how precisely they are initiated and maintained. Here, we briefly sketch our current knowledge on structure and dynamics of different protrusions as well as their regulation by Rho-GTPases. We also comment on topical, unresolved controversies in the field, with special emphasis on the interrelation of different protrusion types, and on the composition of the nanomachineries driving them.
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshCell Movementen
dc.subject.meshMiceen
dc.subject.meshPseudopodiaen
dc.subject.meshrho GTP-Binding Proteinsen
dc.titleOn the Rho'd: the regulation of membrane protrusions by Rho-GTPases.en
dc.typeArticleen
dc.contributor.departmentCytoskeleton Dynamics Group, Helmholtz Centre for Infection Research (HZI), Inhoffen Strasse 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalFEBS lettersen
refterms.dateFOA2018-06-12T23:25:43Z
html.description.abstractCell migration entails the formation of cellular protrusions such as lamellipodia or filopodia, the growth of which is powered by the polymerisation of actin filaments abutting the plasma membrane. Specific Rho-GTPase subfamilies are able to drive different types of protrusions. However, significant crosstalk between Rho-family members and the interplay of distinct Rho-effectors regulating or modulating actin reorganization in protrusions complicate the picture of how precisely they are initiated and maintained. Here, we briefly sketch our current knowledge on structure and dynamics of different protrusions as well as their regulation by Rho-GTPases. We also comment on topical, unresolved controversies in the field, with special emphasis on the interrelation of different protrusion types, and on the composition of the nanomachineries driving them.


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Ladwein & Rottner_final.pdf
Size:
936.2Kb
Format:
PDF
Description:
original manuscript

This item appears in the following Collection(s)

Show simple item record