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dc.contributor.authorGross, Roy
dc.contributor.authorGuzman, Carlos A
dc.contributor.authorSebaihia, Mohammed
dc.contributor.authordos Santos, Vítor A P Martins
dc.contributor.authorPieper, Dietmar H
dc.contributor.authorKoebnik, Ralf
dc.contributor.authorLechner, Melanie
dc.contributor.authorBartels, Daniela
dc.contributor.authorBuhrmester, Jens
dc.contributor.authorChoudhuri, Jomuna V
dc.contributor.authorEbensen, Thomas
dc.contributor.authorGaigalat, Lars
dc.contributor.authorHerrmann, Stefanie
dc.contributor.authorKhachane, Amit N
dc.contributor.authorLarisch, Christof
dc.contributor.authorLink, Stefanie
dc.contributor.authorLinke, Burkhard
dc.contributor.authorMeyer, Folker
dc.contributor.authorMormann, Sascha
dc.contributor.authorNakunst, Diana
dc.contributor.authorRückert, Christian
dc.contributor.authorSchneiker-Bekel, Susanne
dc.contributor.authorSchulze, Kai
dc.contributor.authorVorhölter, Frank-Jörg
dc.contributor.authorYevsa, Tetyana
dc.contributor.authorEngle, Jacquelyn T
dc.contributor.authorGoldman, William E
dc.contributor.authorPühler, Alfred
dc.contributor.authorGöbel, Ulf B
dc.contributor.authorGoesmann, Alexander
dc.contributor.authorBlöcker, Helmut
dc.contributor.authorKaiser, Olaf
dc.contributor.authorMartinez-Arias, Rosa
dc.date.accessioned2008-12-11T14:58:24Zen
dc.date.available2008-12-11T14:58:24Zen
dc.date.issued2008en
dc.identifier.citationThe missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae. 2008, 9:449 BMC Genomicsen
dc.identifier.issn1471-2164en
dc.identifier.pmid18826580en
dc.identifier.doi10.1186/1471-2164-9-449en
dc.identifier.urihttp://hdl.handle.net/10033/42254en
dc.description.abstractBACKGROUND: Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic pathogens. B. petrii strains have been isolated from very different environmental niches, including river sediment, polluted soil, marine sponges and a grass root. Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described. RESULTS: In this manuscript we present the results of the analysis of the completely annotated genome sequence of the B. petrii strain DSMZ12804. B. petrii has a mosaic genome of 5,287,950 bp harboring numerous mobile genetic elements, including seven large genomic islands. Four of them are highly related to the clc element of Pseudomonas knackmussii B13, which encodes genes involved in the degradation of aromatics. Though being an environmental isolate, the sequenced B. petrii strain also encodes proteins related to virulence factors of the pathogenic Bordetellae, including the filamentous hemagglutinin, which is a major colonization factor of B. pertussis, and the master virulence regulator BvgAS. However, it lacks all known toxins of the pathogenic Bordetellae. CONCLUSION: The genomic analysis suggests that B. petrii represents an evolutionary link between free-living environmental bacteria and the host-restricted obligate pathogenic Bordetellae. Its remarkable metabolic versatility may enable B. petrii to thrive in very different ecological niches.
dc.language.isoenen
dc.relation.urlhttp://www.biomedcentral.com/1471-2164/9/449en
dc.subject.meshBacterial Proteinsen
dc.subject.meshBase Compositionen
dc.subject.meshBordetellaen
dc.subject.meshBordetella bronchisepticaen
dc.subject.meshBordetella parapertussisen
dc.subject.meshBordetella pertussisen
dc.subject.meshChromosomes, Bacterialen
dc.subject.meshEvolutionen
dc.subject.meshGenes, Bacterialen
dc.subject.meshGenome, Bacterialen
dc.subject.meshGenomic Libraryen
dc.subject.meshInterspersed Repetitive Sequencesen
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshSyntenyen
dc.subject.meshVirulenceen
dc.subject.meshVirulence Factors, Bordetellaen
dc.titleThe missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae.en
dc.typeArticleen
dc.contributor.departmentChair of Microbiology, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. roy@biozentrum.uni-wuerzburg.deen
dc.identifier.journalBMC genomicsen
refterms.dateFOA2018-06-12T18:12:56Z
html.description.abstractBACKGROUND: Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic pathogens. B. petrii strains have been isolated from very different environmental niches, including river sediment, polluted soil, marine sponges and a grass root. Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described. RESULTS: In this manuscript we present the results of the analysis of the completely annotated genome sequence of the B. petrii strain DSMZ12804. B. petrii has a mosaic genome of 5,287,950 bp harboring numerous mobile genetic elements, including seven large genomic islands. Four of them are highly related to the clc element of Pseudomonas knackmussii B13, which encodes genes involved in the degradation of aromatics. Though being an environmental isolate, the sequenced B. petrii strain also encodes proteins related to virulence factors of the pathogenic Bordetellae, including the filamentous hemagglutinin, which is a major colonization factor of B. pertussis, and the master virulence regulator BvgAS. However, it lacks all known toxins of the pathogenic Bordetellae. CONCLUSION: The genomic analysis suggests that B. petrii represents an evolutionary link between free-living environmental bacteria and the host-restricted obligate pathogenic Bordetellae. Its remarkable metabolic versatility may enable B. petrii to thrive in very different ecological niches.


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