Marine biofilm bacteria evade eukaryotic predation by targeted chemical defense.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Webb, Jeremy S
Schupp, Peter J
Phang, Shui Yen
MetadataShow full item record
AbstractMany plants and animals are defended from predation or herbivory by inhibitory secondary metabolites, which in the marine environment are very common among sessile organisms. Among bacteria, where there is the greatest metabolic potential, little is known about chemical defenses against bacterivorous consumers. An emerging hypothesis is that sessile bacterial communities organized as biofilms serve as bacterial refuge from predation. By testing growth and survival of two common bacterivorous nanoflagellates, we find evidence that chemically mediated resistance against protozoan predators is common among biofilm populations in a diverse set of marine bacteria. Using bioassay-guided chemical and genetic analysis, we identified one of the most effective antiprotozoal compounds as violacein, an alkaloid that we demonstrate is produced predominately within biofilm cells. Nanomolar concentrations of violacein inhibit protozoan feeding by inducing a conserved eukaryotic cell death program. Such biofilm-specific chemical defenses could contribute to the successful persistence of biofilm bacteria in various environments and provide the ecological and evolutionary context for a number of eukaryote-targeting bacterial metabolites.
CitationMarine biofilm bacteria evade eukaryotic predation by targeted chemical defense. 2008, 3 (7):e2744 PLoS ONE
AffiliationSchool of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, Sydney, Australia.
The following license files are associated with this item:
- Overview of the chemical ecology of benthic marine invertebrates along the western Antarctic peninsula.
- Authors: McClintock JB, Amsler CD, Baker BJ
- Issue date: 2010 Dec
- Antimicrobial activity of surface attached marine bacteria in biofilms.
- Authors: Wilson GS, Raftos DA, Nair SV
- Issue date: 2011 Sep 20
- Impact of violacein-producing bacteria on survival and feeding of bacterivorous nanoflagellates.
- Authors: Matz C, Deines P, Boenigk J, Arndt H, Eberl L, Kjelleberg S, Jürgens K
- Issue date: 2004 Mar
- Composition and distribution of bacteria in an operating rainwater harvesting tank.
- Authors: Kim M, Han M
- Issue date: 2011
- [Bacterial biofilms as a natural form of existence of bacteria in the environment and host organism].
- Authors: Romanova IuM, Gintsburg AL
- Issue date: 2011 May-Jun