CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo.
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Best, Shannon E
Amante, Fiona H
de Labastida, Fabian
Hill, Geoffrey R
Engwerda, Christian R
MetadataShow full item record
AbstractStudies in malaria patients indicate that higher frequencies of peripheral blood CD4(+) Foxp3(+) CD25(+) regulatory T (Treg) cells correlate with increased blood parasitemia. This observation implies that Treg cells impair pathogen clearance and thus may be detrimental to the host during infection. In C57BL/6 mice infected with Plasmodium berghei ANKA, depletion of Foxp3(+) cells did not improve parasite control or disease outcome. In contrast, elevating frequencies of natural Treg cells in vivo using IL-2/anti-IL-2 complexes resulted in complete protection against severe disease. This protection was entirely dependent upon Foxp3(+) cells and resulted in lower parasite biomass, impaired antigen-specific CD4(+) T and CD8(+) T cell responses that would normally promote parasite tissue sequestration in this model, and reduced recruitment of conventional T cells to the brain. Furthermore, Foxp3(+) cell-mediated protection was dependent upon CTLA-4 but not IL-10. These data show that T cell-mediated parasite tissue sequestration can be reduced by regulatory T cells in a mouse model of malaria, thereby limiting malaria-induced immune pathology.
CitationCD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. 2010, 6 (12):e1001221 PLoS Pathog.
The following license files are associated with this item:
- A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria.
- Authors: Amante FH, Stanley AC, Randall LM, Zhou Y, Haque A, McSweeney K, Waters AP, Janse CJ, Good MF, Hill GR, Engwerda CR
- Issue date: 2007 Aug
- Suppression of CD4+ Effector Responses by Naturally Occurring CD4+ CD25+ Foxp3+ Regulatory T Cells Contributes to Experimental Cerebral Malaria.
- Authors: Blanc AL, Keswani T, Gorgette O, Bandeira A, Malissen B, Cazenave PA, Pied S
- Issue date: 2016 Jan
- Plasmodium berghei ANKA infection increases Foxp3, IL-10 and IL-2 in CXCL-10 deficient C57BL/6 mice.
- Authors: Sarfo BY, Wilson NO, Bond VC, Stiles JK
- Issue date: 2011 Mar 28
- CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis.
- Authors: Nie CQ, Bernard NJ, Schofield L, Hansen DS
- Issue date: 2007 May
- Role of IL-10-producing regulatory B cells in control of cerebral malaria in Plasmodium berghei infected mice.
- Authors: Liu Y, Chen Y, Li Z, Han Y, Sun Y, Wang Q, Liu B, Su Z
- Issue date: 2013 Nov