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dc.contributor.authorWeiterer, Sebastian
dc.contributor.authorUhle, Florian
dc.contributor.authorLichtenstern, Christoph
dc.contributor.authorSiegler, Benedikt H
dc.contributor.authorBhuju, Sabin
dc.contributor.authorJarek, Michael
dc.contributor.authorBartkuhn, Marek
dc.contributor.authorWeigand, Markus A
dc.date.accessioned2015-04-30T09:27:49Zen
dc.date.available2015-04-30T09:27:49Zen
dc.date.issued2015en
dc.identifier.citationSepsis induces specific changes in histone modification patterns in human monocytes. 2015, 10 (3):e0121748 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid25793379en
dc.identifier.doi10.1371/journal.pone.0121748en
dc.identifier.urihttp://hdl.handle.net/10033/551000en
dc.description.abstractSepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted with a variety of factors, which are integrated within the individual cells and result in changes of their basal state of responsiveness. Epigenetic mechanisms like histone modifications are known to participate in the control of immune reactions, but so far the situation during sepsis is unknown.
dc.language.isoenen
dc.titleSepsis induces specific changes in histone modification patterns in human monocytes.en
dc.typeArticleen
dc.identifier.journalPloS oneen
refterms.dateFOA2018-06-13T00:03:19Z
html.description.abstractSepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted with a variety of factors, which are integrated within the individual cells and result in changes of their basal state of responsiveness. Epigenetic mechanisms like histone modifications are known to participate in the control of immune reactions, but so far the situation during sepsis is unknown.


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