pH-triggered drug release from biodegradable microwells for oral drug delivery.
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Authors
Nielsen, Line HagnerNagstrup, Johan
Gordon, Sarah
Keller, Stephan Sylvest
Østergaard, Jesper
Rades, Thomas
Müllertz, Anette
Boisen, Anja
Issue Date
2015-06
Metadata
Show full item recordAbstract
Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followed by coating of the microwell cavities with a gastro-resistant lid of Eudragit® L100. The release behavior of ASSF from the coated microwells was investigated using a μ-Diss profiler and a UV imaging system, and under conditions simulating the changing environment of the gastrointestinal tract. Biorelevant gastric medium (pH 1.6) was employed, after which a change to biorelevant intestinal release medium (pH 6.5) was carried out. Both μ-Diss profiler and UV imaging release experiments showed that sealing of microwell cavities with an Eudragit® layer prevented drug release in biorelevant gastric medium. An immediate release of the ASSF from coated microwells was observed in the intestinal medium. This pH-triggered release behavior demonstrates the future potential of PLLA microwells as a site-specific oral drug delivery system.Citation
pH-triggered drug release from biodegradable microwells for oral drug delivery. 2015, 17 (3):9958 Biomed MicrodevicesJournal
Biomedical microdevicesPubMed ID
25981751Type
ArticleLanguage
enISSN
1572-8781ae974a485f413a2113503eed53cd6c53
10.1007/s10544-015-9958-5
Scopus Count
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