Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.
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Hornef, Mathias W
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AbstractPriming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the small intestine and quickly acquire a distinct transcriptional profile. T-cell recruitment is independent of microbial colonization and innate or adaptive immune stimulation but requires β7 integrin expression. Surprisingly, neonatal CD4 T cells remain immature throughout the postnatal period under homeostatic conditions but undergo maturation and gain effector function on barrier disruption. Maternal SIgA and regulatory T cells act in concert to prevent immune stimulation and maintain the immature phenotype of CD4 T cells in the postnatal intestine during homeostasis. Active suppression of CD4 T-cell maturation during the postnatal period might contribute to prevent auto-reactivity, sustain a broad TCR repertoire and establish life-long immune homeostasis.
CitationActive suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period. 2015, 6:7725 Nat Commun
AffiliationTWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School, Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Stra e 7, 30625 Hannover, Germany
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