RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection.

Wilk, Esther; Pandey, Ashutosh K; Leist, Sarah Rebecca; Hatesuer, Bastian; Preusse, Matthias; Pommerenke, Claudia; Wang, Junxi; Schughart, Klaus

dc.contributor.author	Wilk, Esther
dc.contributor.author	Pandey, Ashutosh K
dc.contributor.author	Leist, Sarah Rebecca
dc.contributor.author	Hatesuer, Bastian
dc.contributor.author	Preusse, Matthias
dc.contributor.author	Pommerenke, Claudia
dc.contributor.author	Wang, Junxi
dc.contributor.author	Schughart, Klaus
dc.date.accessioned	2015-09-24T15:12:18Z	en
dc.date.available	2015-09-24T15:12:18Z	en
dc.date.issued	2015	en
dc.identifier.citation	RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection. 2015, 16:655 BMC Genomics	en
dc.identifier.issn	1471-2164	en
dc.identifier.pmid	26329040	en
dc.identifier.doi	10.1186/s12864-015-1867-8	en
dc.identifier.uri	http://hdl.handle.net/10033/578689	en
dc.description.abstract	The host response to influenza A infections is strongly influenced by host genetic factors. Animal models of genetically diverse mouse strains are well suited to identify host genes involved in severe pathology, viral replication and immune responses. Here, we have utilized a dual RNAseq approach that allowed us to investigate both viral and host gene expression in the same individual mouse after H1N1 infection.
dc.language.iso	en	en
dc.title	RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection.	en
dc.type	Article	en
dc.contributor.department	Helmholtz Centre for Infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.	en
dc.identifier.journal	BMC genomics	en
refterms.dateFOA	2018-06-13T04:08:35Z
html.description.abstract	The host response to influenza A infections is strongly influenced by host genetic factors. Animal models of genetically diverse mouse strains are well suited to identify host genes involved in severe pathology, viral replication and immune responses. Here, we have utilized a dual RNAseq approach that allowed us to investigate both viral and host gene expression in the same individual mouse after H1N1 infection.