Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.
| dc.contributor.author | Yang, Rui | |
| dc.contributor.author | Lirussi, Dario | |
| dc.contributor.author | Thornton, Tina M | |
| dc.contributor.author | Jelley-Gibbs, Dawn M | |
| dc.contributor.author | Diehl, Sean A | |
| dc.contributor.author | Case, Laure K | |
| dc.contributor.author | Madesh, Muniswamy | |
| dc.contributor.author | Taatjes, Douglas J | |
| dc.contributor.author | Teuscher, Cory | |
| dc.contributor.author | Haynes, Laura | |
| dc.contributor.author | Rincón, Mercedes | |
| dc.date.accessioned | 2015-10-13T14:30:44Z | en |
| dc.date.available | 2015-10-13T14:30:44Z | en |
| dc.date.issued | 2015 | en |
| dc.identifier.citation | Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function. 2015, 4: Elife | en |
| dc.identifier.issn | 2050-084X | en |
| dc.identifier.pmid | 25974216 | en |
| dc.identifier.doi | 10.7554/eLife.06376 | en |
| dc.identifier.uri | http://hdl.handle.net/10033/579603 | en |
| dc.description.abstract | IL-6 plays an important role in determining the fate of effector CD4 cells and the cytokines that these cells produce. Here we identify a novel molecular mechanism by which IL-6 regulates CD4 cell effector function. We show that IL-6-dependent signal facilitates the formation of mitochondrial respiratory chain supercomplexes to sustain high mitochondrial membrane potential late during activation of CD4 cells. Mitochondrial hyperpolarization caused by IL-6 is uncoupled from the production of ATP by oxidative phosphorylation. However, it is a mechanism to raise the levels of mitochondrial Ca(2+) late during activation of CD4 cells. Increased levels of mitochondrial Ca(2+) in the presence of IL-6 are used to prolong Il4 and Il21 expression in effector CD4 cells. Thus, the effect of IL-6 on mitochondrial membrane potential and mitochondrial Ca(2+) is an alternative pathway by which IL-6 regulates effector function of CD4 cells and it could contribute to the pathogenesis of inflammatory diseases. | |
| dc.language.iso | en | en |
| dc.title | Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function. | en |
| dc.type | Article | en |
| dc.contributor.department | Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany. | en |
| dc.identifier.journal | eLife | en |
| refterms.dateFOA | 2018-06-12T22:04:48Z | |
| html.description.abstract | IL-6 plays an important role in determining the fate of effector CD4 cells and the cytokines that these cells produce. Here we identify a novel molecular mechanism by which IL-6 regulates CD4 cell effector function. We show that IL-6-dependent signal facilitates the formation of mitochondrial respiratory chain supercomplexes to sustain high mitochondrial membrane potential late during activation of CD4 cells. Mitochondrial hyperpolarization caused by IL-6 is uncoupled from the production of ATP by oxidative phosphorylation. However, it is a mechanism to raise the levels of mitochondrial Ca(2+) late during activation of CD4 cells. Increased levels of mitochondrial Ca(2+) in the presence of IL-6 are used to prolong Il4 and Il21 expression in effector CD4 cells. Thus, the effect of IL-6 on mitochondrial membrane potential and mitochondrial Ca(2+) is an alternative pathway by which IL-6 regulates effector function of CD4 cells and it could contribute to the pathogenesis of inflammatory diseases. |
