Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.

Martins, José Paulo; Santos, Jorge Miguel; de Almeida, Joana Marto; Filipe, Mariana Alves; de Almeida, Mariana Vargas Teixeira; Almeida, Sílvia Cristina Paiva; Água-Doce, Ana; Varela, Alexandre; Gilljam, Mari; Stellan, Birgitta; Pohl, Susanne; Dittmar, Kurt; Lindenmaier, Werner; Alici, Evren; Graça, Luís; Cruz, Pedro Estilita; Cruz, Helder Joaquim; Bárcia, Rita Nogueira

dc.contributor.author	Martins, José Paulo
dc.contributor.author	Santos, Jorge Miguel
dc.contributor.author	de Almeida, Joana Marto
dc.contributor.author	Filipe, Mariana Alves
dc.contributor.author	de Almeida, Mariana Vargas Teixeira
dc.contributor.author	Almeida, Sílvia Cristina Paiva
dc.contributor.author	Água-Doce, Ana
dc.contributor.author	Varela, Alexandre
dc.contributor.author	Gilljam, Mari
dc.contributor.author	Stellan, Birgitta
dc.contributor.author	Pohl, Susanne
dc.contributor.author	Dittmar, Kurt
dc.contributor.author	Lindenmaier, Werner
dc.contributor.author	Alici, Evren
dc.contributor.author	Graça, Luís
dc.contributor.author	Cruz, Pedro Estilita
dc.contributor.author	Cruz, Helder Joaquim
dc.contributor.author	Bárcia, Rita Nogueira
dc.date.accessioned	2015-10-15T08:26:57Z	en
dc.date.available	2015-10-15T08:26:57Z	en
dc.date.issued	2014	en
dc.identifier.citation	Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data. 2014, 5 (1):9 Stem Cell Res Ther	en
dc.identifier.issn	1757-6512	en
dc.identifier.pmid	24438697	en
dc.identifier.doi	10.1186/scrt398	en
dc.identifier.uri	http://hdl.handle.net/10033/579735	en
dc.description.abstract	Standardization of mesenchymal stromal cells (MSCs) manufacturing is urgently needed to enable translational activities and ultimately facilitate comparison of clinical trial results. In this work we describe the adaptation of a proprietary method for isolation of a specific umbilical cord tissue-derived population of MSCs, herein designated by its registered trademark as UCX®, towards the production of an advanced therapy medicinal product (ATMP).
dc.language.iso	en	en
dc.subject.mesh	Cells, Cultured	en
dc.subject.mesh	Cryopreservation	en
dc.subject.mesh	Humans	en
dc.subject.mesh	Mesenchymal Stem Cell Transplantation	en
dc.subject.mesh	Mesenchymal Stromal Cells	en
dc.subject.mesh	Quality Control	en
dc.subject.mesh	Stem Cell Research	en
dc.subject.mesh	Tissue and Organ Harvesting	en
dc.subject.mesh	Umbilical Cord	en
dc.title	Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.	en
dc.type	Article	en
dc.identifier.journal	Stem cell research & therapy	en
refterms.dateFOA	2018-06-13T14:17:14Z
html.description.abstract	Standardization of mesenchymal stromal cells (MSCs) manufacturing is urgently needed to enable translational activities and ultimately facilitate comparison of clinical trial results. In this work we describe the adaptation of a proprietary method for isolation of a specific umbilical cord tissue-derived population of MSCs, herein designated by its registered trademark as UCX®, towards the production of an advanced therapy medicinal product (ATMP).