The antiviral drug ganciclovir does not inhibit microglial proliferation and activation.
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Salinas Tejedor, Laura
Prajeeth, Chittappen K
Raddatz, Barbara B
Detje, Claudia N
MetadataShow full item record
AbstractGanciclovir is effective in the treatment of human infections with viruses of the Herpesviridae family. Beside antiviral properties, recently ganciclovir was described to inhibit microglial proliferation and disease severity of experimental autoimmune encephalomyelitis, an inflammatory model of multiple sclerosis. Microglial activation and proliferation are main characteristics of neuroinflammatory CNS diseases and inhibition of microglial functions might be beneficial in autoimmune diseases, or detrimental in infectious diseases. The objective of this study was to determine potential inhibitory effects of ganciclovir in three different murine animal models of CNS neuroinflammation in which microglia play an important role: Theiler´s murine encephalomyelitis, the cuprizone model of de- and remyelination, and the vesicular stomatitis virus encephalitis model. In addition, in vitro experiments with microglial cultures were performed to test the hypothesis that ganciclovir inhibits microglial proliferation. In all three animal models, neither microglial proliferation or recruitment nor disease activity was changed by ganciclovir. In vitro experiments confirmed that microglial proliferation was not affected by ganciclovir. In conclusion, our results show that the antiviral drug ganciclovir does not inhibit microglial activation and proliferation in the murine CNS.
CitationThe antiviral drug ganciclovir does not inhibit microglial proliferation and activation. 2015, 5:14935 Sci Rep
AffiliationTWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen Str. 7, 30625, Hannover, Germany.
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- Authors: Wolf Y, Shemer A, Levy-Efrati L, Gross M, Kim JS, Engel A, David E, Chappell-Maor L, Grozovski J, Rotkopf R, Biton I, Eilam-Altstadter R, Jung S
- Issue date: 2018 Aug
- Experimental autoimmune encephalomyelitis repressed by microglial paralysis.
- Authors: Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, Waisman A, Rülicke T, Prinz M, Priller J, Becher B, Aguzzi A
- Issue date: 2005 Feb
- A pivotal role of nonmuscle myosin II during microglial activation.
- Authors: Janßen S, Gudi V, Prajeeth CK, Singh V, Stahl K, Heckers S, Skripuletz T, Pul R, Trebst C, Tsiavaliaris G, Stangel M
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