Negative interactions and feedback regulations are required for transient cellular response.

Mobashir, Mohammad; Madhusudhan, Thati; Isermann, Berend; Beyer, Tilo; Schraven, Burkhart

dc.contributor.author	Mobashir, Mohammad
dc.contributor.author	Madhusudhan, Thati
dc.contributor.author	Isermann, Berend
dc.contributor.author	Beyer, Tilo
dc.contributor.author	Schraven, Burkhart
dc.date.accessioned	2015-11-04T10:51:12Z	en
dc.date.available	2015-11-04T10:51:12Z	en
dc.date.issued	2014	en
dc.identifier.citation	Negative interactions and feedback regulations are required for transient cellular response. 2014, 4:3718 Sci Rep	en
dc.identifier.issn	2045-2322	en
dc.identifier.pmid	24430195	en
dc.identifier.doi	10.1038/srep03718	en
dc.identifier.uri	http://hdl.handle.net/10033/581695	en
dc.description.abstract	Signal transduction is a process required to conduct information from a receptor to the nucleus. This process is vital for the control of cellular function and fate. The dynamics of signaling activation and inhibition determine processes such as apoptosis, proliferation, and differentiation. Thus, it is important to understand the factors modulating transient and sustained response. To address this question, by applying mathematical approach we have studied the factors which can alter the activation nature of downstream signaling molecules. The factors which we have investigated are loops (feed forward and feedback loops), cross-talk of signal transduction pathways, and the change in the concentration of the signaling molecules. Based on our results we conclude that among these factors feedback loop and the cross-talks which directly inhibit the target protein dominantly controls the transient cellular response.
dc.language.iso	en	en
dc.subject.mesh	Cell Physiological Phenomena	en
dc.subject.mesh	Feedback, Physiological	en
dc.subject.mesh	Models, Biological	en
dc.subject.mesh	Signal Transduction	en
dc.title	Negative interactions and feedback regulations are required for transient cellular response.	en
dc.type	Article	en
dc.contributor.department	Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.	en
dc.identifier.journal	Scientific reports	en
refterms.dateFOA	2018-06-13T02:37:26Z
html.description.abstract	Signal transduction is a process required to conduct information from a receptor to the nucleus. This process is vital for the control of cellular function and fate. The dynamics of signaling activation and inhibition determine processes such as apoptosis, proliferation, and differentiation. Thus, it is important to understand the factors modulating transient and sustained response. To address this question, by applying mathematical approach we have studied the factors which can alter the activation nature of downstream signaling molecules. The factors which we have investigated are loops (feed forward and feedback loops), cross-talk of signal transduction pathways, and the change in the concentration of the signaling molecules. Based on our results we conclude that among these factors feedback loop and the cross-talks which directly inhibit the target protein dominantly controls the transient cellular response.