NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
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Authors
Simma, NarasimhuluBose, Tanima
Kahlfuss, Sascha
Mankiewicz, Judith
Lowinus, Theresa
Lühder, Fred
Schüler, Thomas
Schraven, Burkhart
Heine, Martin
Bommhardt, Ursula
Issue Date
2014
Metadata
Show full item recordAbstract
B cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation of B-cell function could be an effective regimen in therapeutic strategies. Since the non-competitive NMDAR antagonist memantine is clinically applied to treat advanced Alzheimer`s disease and ketamine is supposed to improve the course of resistant depression, it is important to know how these drugs affect B-cell function.Citation
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. 2014, 12:75 Cell Commun. SignalAffiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.PubMed ID
25477292Type
ArticleLanguage
enISSN
1478-811Xae974a485f413a2113503eed53cd6c53
10.1186/s12964-014-0075-5
Scopus Count
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