Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.
| dc.contributor.author | Marandu, Thomas F | |
| dc.contributor.author | Oduro, Jennifer D | |
| dc.contributor.author | Borkner, Lisa | |
| dc.contributor.author | Dekhtiarenko, Iryna | |
| dc.contributor.author | Uhrlaub, Jennifer L | |
| dc.contributor.author | Drabig, Anja | |
| dc.contributor.author | Kröger, Andrea | |
| dc.contributor.author | Nikolich-Zugich, Janko | |
| dc.contributor.author | Cicin-Sain, Luka | |
| dc.date.accessioned | 2015-11-09T13:51:23Z | en |
| dc.date.available | 2015-11-09T13:51:23Z | en |
| dc.date.issued | 2015-11-15 | en |
| dc.identifier.citation | Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections. 2015, 89 (22):11715-7 J. Virol. | en |
| dc.identifier.issn | 1098-5514 | en |
| dc.identifier.pmid | 26339051 | en |
| dc.identifier.doi | 10.1128/JVI.01989-15 | en |
| dc.identifier.uri | http://hdl.handle.net/10033/581961 | en |
| dc.description.abstract | Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients. | |
| dc.language.iso | en | en |
| dc.title | Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections. | en |
| dc.type | Article | en |
| dc.contributor.department | Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany. | en |
| dc.identifier.journal | Journal of virology | en |
| refterms.dateFOA | 2016-05-15T00:00:00Z | |
| html.description.abstract | Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients. |
Files in this item
Name:
Marandu et al_final.pdf
Size:
911.0Kb
Format:
PDF
Description:
allowed publisher's PDF