Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.
dc.contributor.author | Prajeeth, Chittappen K | |
dc.contributor.author | Beineke, Andreas | |
dc.contributor.author | Iskandar, Cut Dahlia | |
dc.contributor.author | Gudi, Viktoria | |
dc.contributor.author | Herder, Vanessa | |
dc.contributor.author | Gerhauser, Ingo | |
dc.contributor.author | Haist, Verena | |
dc.contributor.author | Teich, René | |
dc.contributor.author | Huehn, Jochen | |
dc.contributor.author | Baumgärtner, Wolfgang | |
dc.contributor.author | Stangel, Martin | |
dc.date.accessioned | 2016-01-15T14:12:36Z | en |
dc.date.available | 2016-01-15T14:12:36Z | en |
dc.date.issued | 2014 | en |
dc.identifier.citation | Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. 2014, 11:180 J Neuroinflammation | en |
dc.identifier.issn | 1742-2094 | en |
dc.identifier.pmid | 25391297 | en |
dc.identifier.doi | 10.1186/s12974-014-0180-9 | en |
dc.identifier.uri | http://hdl.handle.net/10033/593546 | en |
dc.description.abstract | Theiler's murine encephalomyelitis virus (TMEV) infection represents a commonly used infectious animal model to study various aspects of the pathogenesis of multiple sclerosis (MS). In susceptible SJL mice, dominant activity of Foxp3(+) CD4(+) regulatory T cells (Tregs) in the CNS partly contributes to viral persistence and progressive demyelination. On the other hand, resistant C57BL/6 mice rapidly clear the virus by mounting a strong antiviral immune response. However, very little is known about the role of Tregs in regulating antiviral responses during acute encephalitis in resistant mouse strains. | |
dc.language.iso | en | en |
dc.subject.mesh | Acute Disease | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Cardiovirus Infections | en |
dc.subject.mesh | Disease Resistance | en |
dc.subject.mesh | Encephalitis, Viral | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Mice, Inbred C57BL | en |
dc.subject.mesh | Mice, Transgenic | en |
dc.subject.mesh | T-Lymphocytes, Regulatory | en |
dc.subject.mesh | Theilovirus | en |
dc.title | Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. | en |
dc.type | Article | en |
dc.contributor.department | Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany. | en |
dc.identifier.journal | Journal of neuroinflammation | en |
refterms.dateFOA | 2018-06-18T08:16:26Z | |
html.description.abstract | Theiler's murine encephalomyelitis virus (TMEV) infection represents a commonly used infectious animal model to study various aspects of the pathogenesis of multiple sclerosis (MS). In susceptible SJL mice, dominant activity of Foxp3(+) CD4(+) regulatory T cells (Tregs) in the CNS partly contributes to viral persistence and progressive demyelination. On the other hand, resistant C57BL/6 mice rapidly clear the virus by mounting a strong antiviral immune response. However, very little is known about the role of Tregs in regulating antiviral responses during acute encephalitis in resistant mouse strains. |