FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Probst, Hans Christian
van den Broek, Maries
MetadataShow full item record
AbstractPeripheral T-cell tolerance is thought to significantly contribute to the prevention of autoimmunity, and it has been shown that antigen-presenting steady-state dendritic cells efficiently induce peripheral tolerance. We previously showed that dendritic-cell-induced tolerance is a T-cell-intrinsic process that depends on coinhibitory molecules such as programmed death-1. Here we specifically analyze the involvement of FoxP3(+) regulatory T cells, which are known to be important for maintenance of self-tolerance. We show that antigen presentation by steady-state dendritic cells failed to induce peripheral tolerance in the absence of FoxP3(+) regulatory T cells but induced protective CD8(+) T-cell-mediated immunity instead. Regulatory T-cell-depleted mice had massively increased numbers of dendritic cells in lymph nodes. Dendritic cells isolated from mice without regulatory T cells had up-regulated costimulatory molecules and showed stronger T-cell stimulatory capacity ex vivo, suggesting that regulatory T cells contribute to peripheral tolerance by keeping the dendritic cells in an immature state. Using blocking antibodies, we demonstrate that CTLA-4 but not IL-10 is necessary for control of dendritic cells by regulatory T cells.
CitationFoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells. 2010, 107 (1):199-203 Proc. Natl. Acad. Sci. U.S.A.
AffiliationTWINCORE, Centre for Experimental and Clinical Infection Research GmbH, Feodor-Lynen-Str. 3-7, 30625 Hannover, Germany.
The following license files are associated with this item:
- CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation.
- Authors: Tosiek MJ, Gruber AD, Bader SR, Mauel S, Hoymann HG, Prettin S, Tschernig T, Buer J, Gereke M, Bruder D
- Issue date: 2011 Jun 1
- CTLA-4 control over Foxp3+ regulatory T cell function.
- Authors: Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S
- Issue date: 2008 Oct 10
- Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo.
- Authors: Jaen O, Rullé S, Bessis N, Zago A, Boissier MC, Falgarone G
- Issue date: 2009 Jan
- Antigens expressed by myelinating glia cells induce peripheral cross-tolerance of endogenous CD8+ T cells.
- Authors: Schildknecht A, Probst HC, McCoy KD, Miescher I, Brenner C, Leone DP, Suter U, Ohashi PS, van den Broek M
- Issue date: 2009 Jun
- Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis.
- Authors: Zierden M, Kühnen E, Odenthal M, Dienes HP
- Issue date: 2010 Sep