Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature.
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AuthorsMöller, Jana C
Cron, Randy Q
Young, Daniel W
Girschick, Hermann J
Levy, Deborah M
Sherry, David D
MetadataShow full item record
AbstractSpinal epidural lipomatosis is a rare complication of chronic corticosteroid treatment. We report a new pediatric case and an analysis of this and 19 pediatric cases identified in the international literature. The youngest of these combined 20 patients was 5 years old when lipomatosis was diagnosed. Lipomatosis manifested after a mean of 1.3 (+/- 1.5) years (SD) (median, 0.8 years; range, 3 weeks - 6.5 years) of corticosteroid treatment. The corticosteroid dose at the time of presentation of the lipomatosis ranged widely, between 5 and 80 mg of prednisone/day. Back pain was the most common presenting symptom. Imaging revealed that lipomatosis almost always involved the thoracic spine, extending into the lumbosacral region in a subset of patients. Predominantly lumbosacral involvement was documented in only two cases. Although a neurological deficit at presentation was documented in about half of the cases, surgical decompression was not performed in the cases reported after 1996. Instead, reducing the corticosteroid dose (sometimes combined with dietary restriction to mobilize fat) sufficed to induce remission. In summary, pediatric spinal epidural lipomatosis remains a potentially serious untoward effect of corticosteroid treatment, which, if recognized in a timely manner, can have a good outcome with conservative treatment.
CitationCorticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature. 2011, 9 (1):5 Pediatr Rheumatol Online J
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
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- Paget disease of the spine manifested by thoracic and lumbar epidural lipomatosis: magnetic resonance imaging findings.
- Authors: Oikonomou A, Birbilis T, Gymnopoulou E, Prassopoulos P
- Issue date: 2007 Dec 1
- [Steroid-induced spinal epidural lipomatosis in pediatric patients].
- Authors: Möller J, Girschick HJ, Hahn G, Pessler F
- Issue date: 2010 Jul
- [Epidural lipomatosis].
- Authors: Lévy-Weil FE, Feldmann JL
- Issue date: 2000 Mar 11
- Spinal epidural lipomatosis as a complication of prolonged corticosteroid therapy.
- Authors: Zentner J, Buchbender K, Vahlensieck M
- Issue date: 1995 Mar
- Epidural lipomatosis not induced by corticosteroid therapy. Three cases including one in a patient with primary Cushing's disease (review of the literature).
- Authors: Benamou PH, Hilliquin P, Chemla N, Chevrot A, Cormier C, Menkès CJ
- Issue date: 1996 Mar