Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles.

Guillot, Alexis; Couffin, Anne-Claude; Sejean, Xavier; Navarro, Fabrice; Limberger, Markus; Lehr, Claus-Michael

dc.contributor.author	Guillot, Alexis
dc.contributor.author	Couffin, Anne-Claude
dc.contributor.author	Sejean, Xavier
dc.contributor.author	Navarro, Fabrice
dc.contributor.author	Limberger, Markus
dc.contributor.author	Lehr, Claus-Michael
dc.date.accessioned	2016-02-09T15:11:50Z	en
dc.date.available	2016-02-09T15:11:50Z	en
dc.date.issued	2015-12	en
dc.identifier.citation	Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles. 2015, 32 (12):3999-4009 Pharm. Res.	en
dc.identifier.issn	1573-904X	en
dc.identifier.pmid	26202518	en
dc.identifier.doi	10.1007/s11095-015-1761-8	en
dc.identifier.uri	http://hdl.handle.net/10033/595966	en
dc.description.abstract	Contrary to physical characterization techniques for nanopharmaceuticals (shape, size and zeta-potential), the techniques to quantify the free and the entrapped drug remain very few and difficult to transpose in routine analytical laboratories. The application of Solid Phase Extraction (SPE) technique was investigated to overcome this challenge.
dc.language.iso	en	en
dc.title	Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles.	en
dc.type	Article	en
dc.contributor.department	Helmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.	en
dc.identifier.journal	Pharmaceutical research	en
refterms.dateFOA	2016-08-01T00:00:00Z
html.description.abstract	Contrary to physical characterization techniques for nanopharmaceuticals (shape, size and zeta-potential), the techniques to quantify the free and the entrapped drug remain very few and difficult to transpose in routine analytical laboratories. The application of Solid Phase Extraction (SPE) technique was investigated to overcome this challenge.