Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4⁺ memory T Cells.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
de Goër de Herve, M G
Hernandez-Vargas, Esteban Abelardo
Mateo, M C
Delfraissy, J F
MetadataShow full item record
AbstractIn patients who are receiving prolonged antiretroviral treatment (ART), HIV can persist within a small pool of long-lived resting memory CD4(+) T cells infected with integrated latent virus. This latent reservoir involves distinct memory subsets. Here we provide results that suggest a progressive reduction of the size of the blood latent reservoir around a core of less-differentiated memory subsets (central memory and stem cell-like memory (TSCM) CD4(+) T cells). This process appears to be driven by the differences in initial sizes and decay rates between latently infected memory subsets. Our results also suggest an extreme stability of the TSCM sub-reservoir, the size of which is directly related to cumulative plasma virus exposure before the onset of ART, stressing the importance of early initiation of effective ART. The presence of these intrinsic dynamics within the latent reservoir may have implications for the design of optimal HIV therapeutic purging strategies.
CitationProgressive contraction of the latent HIV reservoir around a core of less-differentiated CD4⁺ memory T Cells. 2014, 5:5407 Nat Commun
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
- HIV DNA subspecies persist in both activated and resting memory CD4+ T cells during antiretroviral therapy.
- Authors: Murray JM, Zaunders JJ, McBride KL, Xu Y, Bailey M, Suzuki K, Cooper DA, Emery S, Kelleher AD, Koelsch KK, PINT Study Team.
- Issue date: 2014 Mar
- Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy.
- Authors: Pierson T, McArthur J, Siliciano RF
- Issue date: 2000
- Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4<sup>+</sup> T Cells.
- Authors: Kulpa DA, Talla A, Brehm JH, Ribeiro SP, Yuan S, Bebin-Blackwell AG, Miller M, Barnard R, Deeks SG, Hazuda D, Chomont N, Sékaly RP
- Issue date: 2019 Dec 15
- CD161<sup>+</sup> CD4<sup>+</sup> T Cells Harbor Clonally Expanded Replication-Competent HIV-1 in Antiretroviral Therapy-Suppressed Individuals.
- Authors: Li X, Liu Z, Li Q, Hu R, Zhao L, Yang Y, Zhao J, Huang Z, Gao H, Li L, Cai W, Deng K
- Issue date: 2019 Oct 8
- Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.
- Authors: Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer N
- Issue date: 2016 Sep 15