Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4⁺ memory T Cells.
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Authors
Jaafoura, Sde Goër de Herve, M G
Hernandez-Vargas, Esteban Abelardo

Hendel-Chavez, H
Abdoh, M
Mateo, M C
Krzysiek, R
Merad, M
Seng, R
Tardieu, M
Delfraissy, J F
Goujard, C
Taoufik, Y
Issue Date
2014
Metadata
Show full item recordAbstract
In patients who are receiving prolonged antiretroviral treatment (ART), HIV can persist within a small pool of long-lived resting memory CD4(+) T cells infected with integrated latent virus. This latent reservoir involves distinct memory subsets. Here we provide results that suggest a progressive reduction of the size of the blood latent reservoir around a core of less-differentiated memory subsets (central memory and stem cell-like memory (TSCM) CD4(+) T cells). This process appears to be driven by the differences in initial sizes and decay rates between latently infected memory subsets. Our results also suggest an extreme stability of the TSCM sub-reservoir, the size of which is directly related to cumulative plasma virus exposure before the onset of ART, stressing the importance of early initiation of effective ART. The presence of these intrinsic dynamics within the latent reservoir may have implications for the design of optimal HIV therapeutic purging strategies.Citation
Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4⁺ memory T Cells. 2014, 5:5407 Nat CommunAffiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.Journal
Nature communicationsPubMed ID
25382623Type
ArticleLanguage
enISSN
2041-1723ae974a485f413a2113503eed53cd6c53
10.1038/ncomms6407
Scopus Count
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