Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.
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AuthorsAxenov-Gibanov, Denis V
Voytsekhovskaya, Irina V
Tokovenko, Bogdan T
Protasov, Eugeniy S
Gamaiunov, Stanislav V
Rebets, Yuriy V
Luzhetskyy, Andriy N
Timofeyev, Maxim A
MetadataShow full item record
AbstractActinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.
CitationActinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. 2016, 11 (2):e0149216 PLoS ONE
AffiliationHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany, 3 Universität des Saarlandes–Pharmazeutische Biotechnologie, Saarbrucken, Germany.
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- Correction: Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.
- Authors: Axenov-Gribanov DV, Voytsekhovskaya IV, Tokovenko BT, Protasov ES, Gamaiunov SV, Rebets YV, Luzhetskyy AN, Timofeyev MA
- Issue date: 2016
- Estimation of antimicrobial activities and fatty acid composition of actinobacteria isolated from water surface of underground lakes from Badzheyskaya and Okhotnichya caves in Siberia.
- Authors: Voytsekhovskaya IV, Axenov-Gribanov DV, Murzina SA, Pekkoeva SN, Protasov ES, Gamaiunov SV, Timofeyev MA
- Issue date: 2018
- Actinobacteria possessing antimicrobial and antioxidant activities isolated from the pollen of scots pine (Pinus sylvestris) grown on the Baikal shore.
- Authors: Axenov-Gribanov DV, Voytsekhovskaya IV, Rebets YV, Tokovenko BT, Penzina TA, Gornostay TG, Adelshin RV, Protasov ES, Luzhetskyy AN, Timofeyev MA
- Issue date: 2016 Oct
- The diversity and antibiotic properties of actinobacteria associated with endemic deepwater amphipods of Lake Baikal.
- Authors: Protasov ES, Axenov-Gribanov DV, Rebets YV, Voytsekhovskaya IV, Tokovenko BT, Shatilina ZM, Luzhetskyy AN, Timofeyev MA
- Issue date: 2017 Dec
- The isolation and characterization of actinobacteria from dominant benthic macroinvertebrates endemic to Lake Baikal.
- Authors: Axenov-Gribanov D, Rebets Y, Tokovenko B, Voytsekhovskaya I, Timofeyev M, Luzhetskyy A
- Issue date: 2016 Mar