Functional modules of sigma factor regulons guarantee adaptability and evolvability.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsBinder, Sebastian C
MetadataShow full item record
AbstractThe focus of modern molecular biology turns from assigning functions to individual genes towards understanding the expression and regulation of complex sets of molecules. Here, we provide evidence that alternative sigma factor regulons in the pathogen Pseudomonas aeruginosa largely represent insulated functional modules which provide a critical level of biological organization involved in general adaptation and survival processes. Analysis of the operational state of the sigma factor network revealed that transcription factors functionally couple the sigma factor regulons and significantly modulate the transcription levels in the face of challenging environments. The threshold quality of newly evolved transcription factors was reached faster and more robustly in in silico testing when the structural organization of sigma factor networks was taken into account. These results indicate that the modular structures of alternative sigma factor regulons provide P. aeruginosa with a robust framework to function adequately in its environment and at the same time facilitate evolutionary change. Our data support the view that widespread modularity guarantees robustness of biological networks and is a key driver of evolvability.
CitationFunctional modules of sigma factor regulons guarantee adaptability and evolvability. 2016, 6:22212 Sci Rep
AffiliationHelmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
- Elucidation of sigma factor-associated networks in Pseudomonas aeruginosa reveals a modular architecture with limited and function-specific crosstalk.
- Authors: Schulz S, Eckweiler D, Bielecka A, Nicolai T, Franke R, Dötsch A, Hornischer K, Bruchmann S, Düvel J, Häussler S
- Issue date: 2015 Mar
- The 'core' and 'accessory' regulons of Pseudomonas-specific extracytoplasmic sigma factors.
- Authors: Cornelis P
- Issue date: 2008 May
- Transcriptional control of the pvdS iron starvation sigma factor gene by the master regulator of sulfur metabolism CysB in Pseudomonas aeruginosa.
- Authors: Imperi F, Tiburzi F, Fimia GM, Visca P
- Issue date: 2010 Jun
- Iron uptake regulation in Pseudomonas aeruginosa.
- Authors: Cornelis P, Matthijs S, Van Oeffelen L
- Issue date: 2009 Feb
- Antisense transcription in Pseudomonas aeruginosa.
- Authors: Eckweiler D, Häussler S
- Issue date: 2018 Jun