Investigations to the Antibacterial Mechanism of Action of Kendomycin.
dc.contributor.author | A Elnakady, Yasser | |
dc.contributor.author | Chatterjee, Indranil | |
dc.contributor.author | Bischoff, Markus | |
dc.contributor.author | Rohde, Manfred | |
dc.contributor.author | Josten, Michaele | |
dc.contributor.author | Sahl, Hans-Georg | |
dc.contributor.author | Herrmann, Mathias | |
dc.contributor.author | Müller, Rolf | |
dc.date.accessioned | 2016-03-09T15:48:40Z | en |
dc.date.available | 2016-03-09T15:48:40Z | en |
dc.date.issued | 2016 | en |
dc.identifier.citation | Investigations to the Antibacterial Mechanism of Action of Kendomycin. 2016, 11 (1):e0146165 PLoS ONE | en |
dc.identifier.issn | 1932-6203 | en |
dc.identifier.pmid | 26795276 | en |
dc.identifier.doi | 10.1371/journal.pone.0146165 | en |
dc.identifier.uri | http://hdl.handle.net/10033/601041 | en |
dc.description.abstract | The emergence of bacteria that are resistant to many currently used drugs emphasizes the need to discover and develop new antibiotics that are effective against such multi-resistant strains. Kendomycin is a novel polyketide that has a unique quinone methide ansa structure and various biological properties. This compound exhibits strong antibacterial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Despite the promise of kendomycinin in several therapeutic areas, its mode of action has yet to be identified. | |
dc.language.iso | en | en |
dc.title | Investigations to the Antibacterial Mechanism of Action of Kendomycin. | en |
dc.type | Article | en |
dc.contributor.department | Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany. | en |
dc.identifier.journal | PloS one | en |
refterms.dateFOA | 2018-06-14T09:19:20Z | |
html.description.abstract | The emergence of bacteria that are resistant to many currently used drugs emphasizes the need to discover and develop new antibiotics that are effective against such multi-resistant strains. Kendomycin is a novel polyketide that has a unique quinone methide ansa structure and various biological properties. This compound exhibits strong antibacterial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Despite the promise of kendomycinin in several therapeutic areas, its mode of action has yet to be identified. |