Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.

Kurhade, Chaitanya; Zegenhagen, Loreen; Weber, Elvira; Nair, Sharmila; Michaelsen-Preusse, Kristin; Spanier, Julia; Gekara, Nelson O; Kröger, Andrea; Överby, Anna K

dc.contributor.author	Kurhade, Chaitanya
dc.contributor.author	Zegenhagen, Loreen
dc.contributor.author	Weber, Elvira
dc.contributor.author	Nair, Sharmila
dc.contributor.author	Michaelsen-Preusse, Kristin
dc.contributor.author	Spanier, Julia
dc.contributor.author	Gekara, Nelson O
dc.contributor.author	Kröger, Andrea
dc.contributor.author	Överby, Anna K
dc.date.accessioned	2016-03-10T15:28:49Z	en
dc.date.available	2016-03-10T15:28:49Z	en
dc.date.issued	2016	en
dc.identifier.citation	Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. 2016, 13 (1):22 J Neuroinflammation	en
dc.identifier.issn	1742-2094	en
dc.identifier.pmid	26819220	en
dc.identifier.doi	10.1186/s12974-016-0487-9	en
dc.identifier.uri	http://hdl.handle.net/10033/601142	en
dc.description.abstract	Although type I interferons (IFNs)-key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adaptor for retinoid-inducible gene I (RIG-I)-like receptor signaling. In this study, we investigate the relative contribution of IPS-1 in the innate immune response in the different brain regions during infection with tick-borne encephalitis virus (TBEV), a flavivirus that causes a variety of severe symptoms like hemorrhagic fevers, encephalitis, and meningitis in the human host.
dc.language.iso	en	en
dc.title	Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.	en
dc.type	Article	en
dc.contributor.department	Helmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.	en
dc.identifier.journal	Journal of neuroinflammation	en
refterms.dateFOA	2018-06-12T18:01:17Z
html.description.abstract	Although type I interferons (IFNs)-key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adaptor for retinoid-inducible gene I (RIG-I)-like receptor signaling. In this study, we investigate the relative contribution of IPS-1 in the innate immune response in the different brain regions during infection with tick-borne encephalitis virus (TBEV), a flavivirus that causes a variety of severe symptoms like hemorrhagic fevers, encephalitis, and meningitis in the human host.