Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.

Leist, Sarah R; Pilzner, Carolin; van den Brand, Judith M A; Dengler, Leonie; Geffers, Robert; Kuiken, Thijs; Balling, Rudi; Kollmus, Heike; Schughart, Klaus

dc.contributor.author	Leist, Sarah R
dc.contributor.author	Pilzner, Carolin
dc.contributor.author	van den Brand, Judith M A
dc.contributor.author	Dengler, Leonie
dc.contributor.author	Geffers, Robert
dc.contributor.author	Kuiken, Thijs
dc.contributor.author	Balling, Rudi
dc.contributor.author	Kollmus, Heike
dc.contributor.author	Schughart, Klaus
dc.date.accessioned	2016-03-11T14:59:02Z	en
dc.date.available	2016-03-11T14:59:02Z	en
dc.date.issued	2016	en
dc.identifier.citation	Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. 2016, 17 (1):143 BMC Genomics	en
dc.identifier.issn	1471-2164	en
dc.identifier.pmid	26921172	en
dc.identifier.doi	10.1186/s12864-016-2483-y	en
dc.identifier.uri	http://hdl.handle.net/10033/601218	en
dc.description.abstract	Influenza A virus is a zoonotic pathogen that poses a major threat to human and animal health. The severe course of influenza infection is not only influenced by viral virulence factors but also by individual differences in the host response. To determine the extent to which the genetic background can modulate severity of an infection, we studied the host responses to influenza infections in the eight genetically highly diverse Collaborative Cross (CC) founder mouse strains.
dc.language.iso	en	en
dc.title	Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.	en
dc.type	Article	en
dc.contributor.department	Helmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.	en
dc.identifier.journal	BMC genomics	en
refterms.dateFOA	2018-06-13T00:12:28Z
html.description.abstract	Influenza A virus is a zoonotic pathogen that poses a major threat to human and animal health. The severe course of influenza infection is not only influenced by viral virulence factors but also by individual differences in the host response. To determine the extent to which the genetic background can modulate severity of an infection, we studied the host responses to influenza infections in the eight genetically highly diverse Collaborative Cross (CC) founder mouse strains.