LC/MS Based Monitoring of Endogenous Decay Markers for Quality Assessment of Serum Specimens
Name:
supplemental figure_1.tif
Size:
60.92Kb
Format:
TIFF image
Description:
supplemental fig. 1
Name:
Supplemental_Figure_2A.tif
Size:
237.9Kb
Format:
TIFF image
Description:
supplemental fig. 2A
Name:
Supplemental_Figure_2B.tif
Size:
279.0Kb
Format:
TIFF image
Description:
supplemental fig. 2B
Name:
Supplemental_Figure_2C.tif
Size:
230.7Kb
Format:
TIFF image
Description:
supplemental fig. 2C
Name:
Supplemental_Figure_2D.tif
Size:
251.6Kb
Format:
TIFF image
Description:
supplemental fig. 2D
Abstract
Preanalytical variations have major impact on most biological assays. Specifically MS-based multiparametric proteomics analyses of blood specimens are seriously affected by limited protein stability due to high intrinsic proteolytic activity of serum and plasma. However, the direct analysis of sample quality (DASQ) for serum specimens is not readily available. Here we propose the mass spectrometry based monitoring of peptide patterns that are ex vivo changing in a time dependent manner to alleviate these constrains.Citation
LC/MS Based Monitoring of Endogenous Decay Markers for Quality Assessment of Serum Specimens 2015, 08 (05) Journal of Proteomics & BioinformaticsAffiliation
1Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, GermanyType
ArticleISSN
0974276XScopus Count
The following license files are associated with this item: