Atypical IκB proteins in immune cell differentiation and function.
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Authors
Annemann, MichaelaPlaza-Sirvent, Carlos
Schuster, Marc
Katsoulis-Dimitriou, Konstantinos
Kliche, Stefanie
Schraven, Burkhart
Schmitz, Ingo
Issue Date
2016-03
Metadata
Show full item recordAbstract
The NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.Citation
Atypical IκB proteins in immune cell differentiation and function. 2016, 171:26-35 Immunol. Lett.Journal
Immunology lettersPubMed ID
26804211Type
ArticleLanguage
enISSN
1879-0542ae974a485f413a2113503eed53cd6c53
10.1016/j.imlet.2016.01.006
Scopus Count
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