Atypical IκB proteins in immune cell differentiation and function.

Annemann, Michaela; Plaza-Sirvent, Carlos; Schuster, Marc; Katsoulis-Dimitriou, Konstantinos; Kliche, Stefanie; Schraven, Burkhart; Schmitz, Ingo

dc.contributor.author	Annemann, Michaela
dc.contributor.author	Plaza-Sirvent, Carlos
dc.contributor.author	Schuster, Marc
dc.contributor.author	Katsoulis-Dimitriou, Konstantinos
dc.contributor.author	Kliche, Stefanie
dc.contributor.author	Schraven, Burkhart
dc.contributor.author	Schmitz, Ingo
dc.date.accessioned	2016-04-22T13:31:47Z	en
dc.date.available	2016-04-22T13:31:47Z	en
dc.date.issued	2016-03	en
dc.identifier.citation	Atypical IκB proteins in immune cell differentiation and function. 2016, 171:26-35 Immunol. Lett.	en
dc.identifier.issn	1879-0542	en
dc.identifier.pmid	26804211	en
dc.identifier.doi	10.1016/j.imlet.2016.01.006	en
dc.identifier.uri	http://hdl.handle.net/10033/606592	en
dc.description.abstract	The NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.
dc.language.iso	en	en
dc.title	Atypical IκB proteins in immune cell differentiation and function.	en
dc.type	Article	en
dc.identifier.journal	Immunology letters	en
refterms.dateFOA	2017-03-15T00:00:00Z
html.description.abstract	The NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.