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dc.contributor.authorAnnemann, Michaela
dc.contributor.authorPlaza-Sirvent, Carlos
dc.contributor.authorSchuster, Marc
dc.contributor.authorKatsoulis-Dimitriou, Konstantinos
dc.contributor.authorKliche, Stefanie
dc.contributor.authorSchraven, Burkhart
dc.contributor.authorSchmitz, Ingo
dc.date.accessioned2016-04-22T13:31:47Zen
dc.date.available2016-04-22T13:31:47Zen
dc.date.issued2016-03en
dc.identifier.citationAtypical IκB proteins in immune cell differentiation and function. 2016, 171:26-35 Immunol. Lett.en
dc.identifier.issn1879-0542en
dc.identifier.pmid26804211en
dc.identifier.doi10.1016/j.imlet.2016.01.006en
dc.identifier.urihttp://hdl.handle.net/10033/606592en
dc.description.abstractThe NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.
dc.language.isoenen
dc.titleAtypical IκB proteins in immune cell differentiation and function.en
dc.typeArticleen
dc.identifier.journalImmunology lettersen
refterms.dateFOA2017-03-15T00:00:00Z
html.description.abstractThe NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.


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