Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.
| dc.contributor.author | Leist, Sarah R | |
| dc.contributor.author | Kollmus, Heike | |
| dc.contributor.author | Hatesuer, Bastian | |
| dc.contributor.author | Lambertz, Ruth L O | |
| dc.contributor.author | Schughart, Klaus | |
| dc.date.accessioned | 2016-04-25T13:15:55Z | en |
| dc.date.available | 2016-04-25T13:15:55Z | en |
| dc.date.issued | 2016 | en |
| dc.identifier.citation | Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice. 2016, 13 (1):17 Virol. J. | en |
| dc.identifier.issn | 1743-422X | en |
| dc.identifier.pmid | 26817701 | en |
| dc.identifier.doi | 10.1186/s12985-016-0471-0 | en |
| dc.identifier.uri | http://hdl.handle.net/10033/606947 | en |
| dc.description.abstract | Previously, we performed a quantitative trait locus (QTL) mapping study in BXD recombinant inbred mice to identify host genetic factors that confer resistance to influenza A virus infection. We found Lst1 (leukocyte specific transcript 1) as one of the most promising candidate genes in the Qivr17-2 locus because it is non-functional in DBA/2 J mice. Several studies have proposed that LST1 plays a role in the immune response to inflammatory diseases in humans and has additional immune-regulatory functions. Here, we evaluated the relevance of LST1 for the host response to influenza A infection in B6-Lst1 (-/-) mutant mice. | |
| dc.language.iso | en | en |
| dc.title | Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice. | en |
| dc.type | Article | en |
| dc.contributor.department | Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany. | en |
| dc.identifier.journal | Virology journal | en |
| refterms.dateFOA | 2018-06-13T00:54:37Z | |
| html.description.abstract | Previously, we performed a quantitative trait locus (QTL) mapping study in BXD recombinant inbred mice to identify host genetic factors that confer resistance to influenza A virus infection. We found Lst1 (leukocyte specific transcript 1) as one of the most promising candidate genes in the Qivr17-2 locus because it is non-functional in DBA/2 J mice. Several studies have proposed that LST1 plays a role in the immune response to inflammatory diseases in humans and has additional immune-regulatory functions. Here, we evaluated the relevance of LST1 for the host response to influenza A infection in B6-Lst1 (-/-) mutant mice. |
