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dc.contributor.authorFelgner, Sebastian
dc.contributor.authorKocijancic, Dino
dc.contributor.authorFrahm, Michael
dc.contributor.authorWeiss, Siegfried
dc.date.accessioned2016-04-26T14:52:30Zen
dc.date.available2016-04-26T14:52:30Zen
dc.date.issued2016en
dc.identifier.citationBacteria in Cancer Therapy: Renaissance of an Old Concept. 2016, 2016:8451728 Int J Microbiolen
dc.identifier.issn1687-918Xen
dc.identifier.pmid27051423en
dc.identifier.doi10.1155/2016/8451728en
dc.identifier.urihttp://hdl.handle.net/10033/607164en
dc.description.abstractThe rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times and was revived in the 19th century mainly by the pioneer William Coley. This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. In this regard, several perspectives are discussed by which bacteria in addition to their intrinsic antitumor effect can be used as vector systems that shuttle therapeutic compounds into the tumor. Strategic solutions like these provide a sound and more apt exploitation of bacteria that may overcome limitations of conventional therapies.
dc.language.isoenen
dc.titleBacteria in Cancer Therapy: Renaissance of an Old Concept.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalInternational journal of microbiologyen
refterms.dateFOA2018-06-12T21:47:44Z
html.description.abstractThe rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times and was revived in the 19th century mainly by the pioneer William Coley. This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. In this regard, several perspectives are discussed by which bacteria in addition to their intrinsic antitumor effect can be used as vector systems that shuttle therapeutic compounds into the tumor. Strategic solutions like these provide a sound and more apt exploitation of bacteria that may overcome limitations of conventional therapies.


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