Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.
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Authors
Knuschke, TorbenRotan, Olga
Bayer, Wibke
Sokolova, Viktoriya
Hansen, Wiebke
Sparwasser, Tim
Dittmer, Ulf
Epple, Matthias
Buer, Jan
Westendorf, Astrid M
Issue Date
2016
Metadata
Show full item recordAbstract
Regulatory T cells (Tregs) have been shown to limit anti-viral immunity during chronic retroviral infection and to restrict vaccine-induced T cell responses. The objective of the study was to assess whether a combinational therapy of nanoparticle-based therapeutic vaccination and concomitant transient ablation of Tregs augments anti-viral immunity and improves virus control in chronically retrovirus-infected mice. Therefore, chronically Friend retrovirus (FV)-infected mice were immunized with calcium phosphate (CaP) nanoparticles functionalized with TLR9 ligand CpG and CD8(+) or CD4(+) T cell epitope peptides (GagL85-93 or Env gp70123-141) of FV. In addition, Tregs were ablated during the immunization process. Reactivation of CD4(+) and CD8(+) effector T cells was analysed and the viral loads were determined.Citation
Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection. 2016, 13:24 RetrovirologyAffiliation
TWINCORE, Centre for Experimental and Clinical Medicine, 30625 Hannover, Germany.Journal
RetrovirologyPubMed ID
27076190Type
ArticleLanguage
enISSN
1742-4690ae974a485f413a2113503eed53cd6c53
10.1186/s12977-016-0258-9
Scopus Count
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