Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Westendorf, Astrid M
MetadataShow full item record
AbstractRegulatory T cells (Tregs) have been shown to limit anti-viral immunity during chronic retroviral infection and to restrict vaccine-induced T cell responses. The objective of the study was to assess whether a combinational therapy of nanoparticle-based therapeutic vaccination and concomitant transient ablation of Tregs augments anti-viral immunity and improves virus control in chronically retrovirus-infected mice. Therefore, chronically Friend retrovirus (FV)-infected mice were immunized with calcium phosphate (CaP) nanoparticles functionalized with TLR9 ligand CpG and CD8(+) or CD4(+) T cell epitope peptides (GagL85-93 or Env gp70123-141) of FV. In addition, Tregs were ablated during the immunization process. Reactivation of CD4(+) and CD8(+) effector T cells was analysed and the viral loads were determined.
CitationCombination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection. 2016, 13:24 Retrovirology
AffiliationTWINCORE, Centre for Experimental and Clinical Medicine, 30625 Hannover, Germany.
The following license files are associated with this item:
- Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection.
- Authors: Knuschke T, Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning CJ, Hansen W, Dittmer U, Epple M, Buer J, Westendorf AM
- Issue date: 2014 Nov
- Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease.
- Authors: Kawabata H, Niwa A, Tsuji-Kawahara S, Uenishi H, Iwanami N, Matsukuma H, Abe H, Tabata N, Matsumura H, Miyazawa M
- Issue date: 2006 Jan
- Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection.
- Authors: Littwitz E, Francois S, Dittmer U, Gibbert K
- Issue date: 2013 Nov 1
- Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8<sup>+</sup> T Cell Responses During Chronic Retroviral Infection.
- Authors: Knuschke T, Rotan O, Bayer W, Kollenda S, Dickow J, Sutter K, Hansen W, Dittmer U, Lang KS, Epple M, Buer J, Westendorf AM
- Issue date: 2018
- Expanded regulatory T cells in chronically friend retrovirus-infected mice suppress immunity to a murine cytomegalovirus superinfection.
- Authors: Duppach J, Francois S, Joedicke JJ, Dittmer U, Kraft AR
- Issue date: 2014 Dec