Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Czaplewska, Justyna A
Majdanski, Tobias C
Schubert, Ulrich S
MetadataShow full item record
AbstractThe effect of modifying the well-established pharmaceutical polymer PLGA by different PEG-containing block-copolymers on the preparation of ovalbumin (OVA) loaded PLGA nanoparticles (NPs) was studied. The used polymers contained poly(d,l-lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG) and poly(allyl glycidyl ether) (PAGE) as building blocks. The double emulsion technique yielded spherical NPs in the size range from 170 to 220nm (PDI<0.15) for all the differently modified polymers, allowing to directly compare protein loading of and release. PEGylation is usually believed to increase the hydrophilic character of produced particles, favoring encapsulation of hydrophilic substances. However, in this study simple PEGylation of PLGA had only a slight effect on protein release. In contrast, incorporating a PAGE block between the PEG and PLGA units, also eventually enabling active targeting introducing a reactive group, led to a significantly higher loading (+25%) and release rate (+100%), compared to PLGA and PEG-b-PLGA NPs.
CitationImpact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release. 2016, 500 (1-2):187-95 Int J Pharm
The following license files are associated with this item:
- Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity.
- Authors: Rietscher R, Schröder M, Janke J, Czaplewska J, Gottschaldt M, Scherließ R, Hanefeld A, Schubert US, Schneider M, Knolle PA, Lehr CM
- Issue date: 2016 May
- Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin.
- Authors: Liu R, Wang Y, Li X, Bao W, Xia G, Chen W, Cheng J, Xu Y, Guo L, Chen B
- Issue date: 2015
- PEGylation strategies for active targeting of PLA/PLGA nanoparticles.
- Authors: Betancourt T, Byrne JD, Sunaryo N, Crowder SW, Kadapakkam M, Patel S, Casciato S, Brannon-Peppas L
- Issue date: 2009 Oct
- Development and characterization of sorafenib-loaded PLGA nanoparticles for the systemic treatment of liver fibrosis.
- Authors: Lin TsT, Gao DY, Liu YC, Sung YC, Wan D, Liu JY, Chiang T, Wang L, Chen Y
- Issue date: 2016 Jan 10
- Prevention of Oxidized Low Density Lipoprotein-Induced Endothelial Cell Injury by DA-PLGA-PEG-cRGD Nanoparticles Combined with Ultrasound.
- Authors: Li Z, Huang H, Huang L, Du L, Sun Y, Duan Y
- Issue date: 2017 Apr 13