Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractMicroRNAs (miRNAs) represent a class of small non-coding RNA (sncRNA) molecules that can regulate mRNAs by inducing their degradation or by blocking translation. Considering that miRNAs are ubiquitous, stable, and conserved across animal species, it seems feasible to exploit them for clinical applications. Unlike in human viral diseases, where some miRNA-based molecules have progressed to clinical application, in veterinary medicine, this concept is just starting to come into view. Clinically, miRNAs could represent powerful diagnostic tools to pinpoint animal viral diseases and/or prognostic tools to follow up disease progression or remission. Additionally, the possible consequences of miRNA dysregulation make them potential therapeutic targets and open the possibilities to use them as tools to generate viral disease-resistant livestock. This review presents an update of preclinical studies on using sncRNAs to combat viral diseases that affect pet and farm animals. Moreover, we discuss the possibilities and challenges of bringing these bench-based discoveries to the veterinary clinic.
CitationSmall Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications. 2016, 3:22 Front Vet Sci
AffiliationTwincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
JournalFrontiers in veterinary science
The following license files are associated with this item:
- Circulating MicroRNAs As Potential Biomarkers for Veterinary Infectious Diseases.
- Authors: Dong H, Gao Q, Peng X, Sun Y, Han T, Zhao B, Liu Y, Wang C, Song X, Wu J, Yang L
- Issue date: 2017
- MicroRNAs in the Host Response to Viral Infections of Veterinary Importance.
- Authors: Samir M, Vaas LA, Pessler F
- Issue date: 2016
- Why the hype - What are microRNAs and why do they provide unique investigative, diagnostic, and therapeutic opportunities in veterinary medicine?
- Authors: Antunes J, Lee O, Alizadeh AH, LaMarre J, Koch TG
- Issue date: 2020 Aug
- Small non-coding RNAs as important players, biomarkers and therapeutic targets in multiple sclerosis: A comprehensive overview.
- Authors: Piket E, Zheleznyakova GY, Kular L, Jagodic M
- Issue date: 2019 Jul
- Characterizing viral microRNAs and its application on identifying new microRNAs in viruses.
- Authors: Pan X, Zhang B, San Francisco M, Cobb GP
- Issue date: 2007 Apr