Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus.

Bokkasam, Harish; Ernst, Matthias; Guenther, Marco; Wagner, Christian; Schaefer, Ulrich F; Lehr, Claus-Michael

dc.contributor.author	Bokkasam, Harish
dc.contributor.author	Ernst, Matthias
dc.contributor.author	Guenther, Marco
dc.contributor.author	Wagner, Christian
dc.contributor.author	Schaefer, Ulrich F
dc.contributor.author	Lehr, Claus-Michael
dc.date.accessioned	2016-06-28T14:04:30Z
dc.date.available	2016-06-28T14:04:30Z
dc.date.issued	2016-06-13
dc.identifier.citation	Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus. 2016: Int J Pharm	en
dc.identifier.issn	1873-3476
dc.identifier.pmid	27311353
dc.identifier.doi	10.1016/j.ijpharm.2016.06.035
dc.identifier.uri	http://hdl.handle.net/10033/614916
dc.description.abstract	Aim of this study was to investigate the similarities and differences at macro- and microscale in the viscoelastic properties of mucus that covers the epithelia of the intestinal and respiratory tract. Natural mucus was collected from pulmonary and intestinal regions of healthy pigs. Macro-rheological investigations were carried out through conventional plate-plate rheometry. Microrheology was investigated using optical tweezers. Our data revealed significant differences both in macro- and micro-rheological properties between respiratory and intestinal mucus.
dc.language	ENG
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus.
dc.type	Article	en
dc.contributor.department	Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus E8.1, 66123 Saarbrücken.	en
dc.identifier.journal	International journal of pharmaceutics	en
refterms.dateFOA	2017-06-15T00:00:00Z
html.description.abstract	Aim of this study was to investigate the similarities and differences at macro- and microscale in the viscoelastic properties of mucus that covers the epithelia of the intestinal and respiratory tract. Natural mucus was collected from pulmonary and intestinal regions of healthy pigs. Macro-rheological investigations were carried out through conventional plate-plate rheometry. Microrheology was investigated using optical tweezers. Our data revealed significant differences both in macro- and micro-rheological properties between respiratory and intestinal mucus.