Biodegradable chitosan nanoparticle coatings on titanium for the delivery of BMP-2.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractA simple method for the functionalization of a common implant material (Ti6Al4V) with biodegradable, drug loaded chitosan-tripolyphosphate (CS-TPP) nanoparticles is developed in order to enhance the osseointegration of endoprostheses after revision operations. The chitosan used has a tailored degree of acetylation which allows for a fast biodegradation by lysozyme. The degradability of chitosan is proven via viscometry. Characteristics and degradation of nanoparticles formed with TPP are analyzed using dynamic light scattering. The particle degradation via lysozyme displays a decrease in particle diameter of 40% after 4 days. Drug loading and release is investigated for the nanoparticles with bone morphogenetic protein 2 (BMP-2), using ELISA and the BRE luciferase test for quantification and bioactivity evaluation. Furthermore, nanoparticle coatings on titanium substrates are created via spray-coating and analyzed by ellipsometry, scanning electron microscopy and X-ray photoelectron spectroscopy. Drug loaded nanoparticle coatings with biologically active BMP-2 are obtained in vitro within this work. Additionally, an in vivo study in mice indicates the dose dependent induction of ectopic bone growth through CS-TPP-BMP-2 nanoparticles. These results show that biodegradable CS-TPP coatings can be utilized to present biologically active BMP-2 on common implant materials like Ti6Al4V.
CitationBiodegradable chitosan nanoparticle coatings on titanium for the delivery of BMP-2. 2015, 5 (1):3-19 Biomolecules
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Preparation of BMP-2/chitosan/hydroxyapatite antibacterial bio-composite coatings on titanium surfaces for bone tissue engineering.
- Authors: Wang X, Li B, Zhang C
- Issue date: 2019 Oct 26
- Osteogenetic property of a biodegradable three-dimensional macroporous hydrogel coating on titanium implants fabricated via EPD.
- Authors: Ma K, Cai X, Zhou Y, Zhang Z, Jiang T, Wang Y
- Issue date: 2014 Feb
- TiO2 nanotubes as drug nanoreservoirs for the regulation of mobility and differentiation of mesenchymal stem cells.
- Authors: Hu Y, Cai K, Luo Z, Xu D, Xie D, Huang Y, Yang W, Liu P
- Issue date: 2012 Jan
- Fabrication and characterization of Mg-doped chitosan-gelatin nanocompound coatings for titanium surface functionalization.
- Authors: Cai X, Cai J, Ma K, Huang P, Gong L, Huang D, Jiang T, Wang Y
- Issue date: 2016 Jul
- Chitosan nanoparticle as protein delivery carrier--systematic examination of fabrication conditions for efficient loading and release.
- Authors: Gan Q, Wang T
- Issue date: 2007 Sep 1