Early changes in the metabolic profile of activated CD8(+) T cells.
dc.contributor.author | Cammann, Clemens | |
dc.contributor.author | Rath, Alexander | |
dc.contributor.author | Reichl, Udo | |
dc.contributor.author | Lingel, Holger | |
dc.contributor.author | Brunner-Weinzierl, Monika | |
dc.contributor.author | Simeoni, Luca | |
dc.contributor.author | Schraven, Burkhart | |
dc.contributor.author | Lindquist, Jonathan A | |
dc.date.accessioned | 2016-07-15T09:40:17Z | |
dc.date.available | 2016-07-15T09:40:17Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Early changes in the metabolic profile of activated CD8(+) T cells. 2016, 17 (1):28 BMC Cell Biol. | en |
dc.identifier.issn | 1471-2121 | |
dc.identifier.pmid | 27387758 | |
dc.identifier.doi | 10.1186/s12860-016-0104-x | |
dc.identifier.uri | http://hdl.handle.net/10033/616990 | |
dc.description.abstract | Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accomplish this task, T cells require dramatic changes in metabolism. Therefore, we investigated changes of metabolic intermediates indicating for crucial metabolic pathways reflecting the status of T cells. Moreover we analyzed possible regulatory molecules required for the initiation of the metabolic changes. | |
dc.language.iso | en | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | Early changes in the metabolic profile of activated CD8(+) T cells. | en |
dc.type | Article | en |
dc.contributor.department | Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany. | en |
dc.identifier.journal | BMC cell biology | en |
refterms.dateFOA | 2018-06-12T23:51:17Z | |
html.description.abstract | Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accomplish this task, T cells require dramatic changes in metabolism. Therefore, we investigated changes of metabolic intermediates indicating for crucial metabolic pathways reflecting the status of T cells. Moreover we analyzed possible regulatory molecules required for the initiation of the metabolic changes. |