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    Evolution of 2009 H1N1 influenza viruses during the pandemic correlates with increased viral pathogenicity and transmissibility in the ferret model.

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    Authors
    Otte, Anna
    Marriott, Anthony C
    Dreier, Carola
    Dove, Brian
    Mooren, Kyra
    Klingen, Thorsten R
    Sauter, Martina
    Thompson, Katy-Anne
    Bennett, Allan
    Klingel, Karin
    van Riel, Debby
    McHardy, Alice C
    Carroll, Miles W
    Gabriel, Gülsah
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    Issue Date
    2016
    
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    Abstract
    There is increasing evidence that 2009 pandemic H1N1 influenza viruses have evolved after pandemic onset giving rise to severe epidemics in subsequent waves. However, it still remains unclear which viral determinants might have contributed to disease severity after pandemic initiation. Here, we show that distinct mutations in the 2009 pandemic H1N1 virus genome have occurred with increased frequency after pandemic declaration. Among those, a mutation in the viral hemagglutinin was identified that increases 2009 pandemic H1N1 virus binding to human-like α2,6-linked sialic acids. Moreover, these mutations conferred increased viral replication in the respiratory tract and elevated respiratory droplet transmission between ferrets. Thus, our data show that 2009 H1N1 influenza viruses have evolved after pandemic onset giving rise to novel virus variants that enhance viral replicative fitness and respiratory droplet transmission in a mammalian animal model. These findings might help to improve surveillance efforts to assess the pandemic risk by emerging influenza viruses.
    Citation
    Evolution of 2009 H1N1 influenza viruses during the pandemic correlates with increased viral pathogenicity and transmissibility in the ferret model. 2016, 6:28583 Sci Rep
    Affiliation
    Viral Zoonoses and Adaptation, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
    Journal
    Scientific reports
    URI
    http://hdl.handle.net/10033/617268
    DOI
    10.1038/srep28583
    PubMed ID
    27339001
    Type
    Article
    Language
    en
    ISSN
    2045-2322
    ae974a485f413a2113503eed53cd6c53
    10.1038/srep28583
    Scopus Count
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    publications of the research group bioinformatics in infection research ([BRICS] BIFO)

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