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dc.contributor.authorGordon, Sarah
dc.contributor.authorDaneshian, Mardas
dc.contributor.authorBouwstra, Joke
dc.contributor.authorCaloni, Francesca
dc.contributor.authorConstant, Samuel
dc.contributor.authorDavies, Donna E
dc.contributor.authorDandekar, Gudrun
dc.contributor.authorGuzman, Carlos A
dc.contributor.authorFabian, Eric
dc.contributor.authorHaltner, Eleonore
dc.contributor.authorHartung, Thomas
dc.contributor.authorHasiwa, Nina
dc.contributor.authorHayden, Patrick
dc.contributor.authorKandarova, Helena
dc.contributor.authorKhare, Sangeeta
dc.contributor.authorKrug, Harald F
dc.contributor.authorKneuer, Carsten
dc.contributor.authorLeist, Marcel
dc.contributor.authorLian, Guoping
dc.contributor.authorMarx, Uwe
dc.contributor.authorMetzger, Marco
dc.contributor.authorOtt, Katharina
dc.contributor.authorPrieto, Pilar
dc.contributor.authorRoberts, Michael S
dc.contributor.authorRoggen, Erwin L
dc.contributor.authorTralau, Tewes
dc.contributor.authorvan den Braak, Claudia
dc.contributor.authorWalles, Heike
dc.contributor.authorLehr, Claus-Michael
dc.date.accessioned2016-07-21T13:21:30Z
dc.date.available2016-07-21T13:21:30Z
dc.date.issued2015
dc.identifier.citationNon-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. 2015, 32 (4):327-78 ALTEXen
dc.identifier.issn1868-596X
dc.identifier.pmid26536291
dc.identifier.urihttp://hdl.handle.net/10033/617325
dc.description.abstractModels of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimal Testing Alternativesen
dc.subject.meshAnimalsen
dc.subject.meshBiomedical Researchen
dc.subject.meshCell Culture Techniquesen
dc.subject.meshEpithelial Cellsen
dc.subject.meshHumansen
dc.subject.meshIntestinesen
dc.subject.meshLungen
dc.subject.meshModels, Animalen
dc.subject.meshPermeabilityen
dc.subject.meshSkinen
dc.subject.meshToxicity Testsen
dc.titleNon-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1,56123 Saarbrücken, Germany.en
dc.identifier.journalALTEXen
refterms.dateFOA2018-06-12T17:18:58Z
html.description.abstractModels of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.


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