Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities.

Mostaghaci, Babak; Loretz, Brigitta; Lehr, Claus-Michael

dc.contributor.author	Mostaghaci, Babak
dc.contributor.author	Loretz, Brigitta
dc.contributor.author	Lehr, Claus-Michael
dc.date.accessioned	2016-08-05T13:38:56Z
dc.date.available	2016-08-05T13:38:56Z
dc.date.issued	2016
dc.identifier.citation	Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities. 2016, 22 (11):1529-33 Curr. Pharm. Des.	en
dc.identifier.issn	1873-4286
dc.identifier.pmid	26654437
dc.identifier.uri	http://hdl.handle.net/10033/617985
dc.description.abstract	Calcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent biocompatibility and simple application have motivated the researchers to always consider this system in their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system. In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to improve the properties of this system are reviewed.
dc.language.iso	en	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities.	en
dc.type	Article	en
dc.contributor.department	Helmholtz Institut f?r Pharmazeutische Forschung Saarland, Universit?tscampus E8.1, 66123 Saarbr?cken, Germany.	en
dc.identifier.journal	Current pharmaceutical design	en
refterms.dateFOA	2017-03-01T00:00:00Z
html.description.abstract	Calcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent biocompatibility and simple application have motivated the researchers to always consider this system in their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system. In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to improve the properties of this system are reviewed.