Exploring the bacterial assemblages along the human nasal passage.
Name:
Dataset S2.xlsx
Size:
102.4Kb
Format:
Microsoft Excel 2007
Description:
supplemental dataset 2
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Wos-Oxley, Melissa LChaves-Moreno, Diego
Jáuregui, Ruy
Oxley, Andrew P A
Kaspar, Ursula
Plumeier, Iris
Kahl, Silke
Rudack, Claudia
Becker, Karsten
Pieper, Dietmar H
Issue Date
2016-07
Metadata
Show full item recordAbstract
The human nasal passage, from the anterior nares through the nasal vestibule to the nasal cavities, is an important habitat for opportunistic pathogens and commensals alike. This work sampled four different anatomical regions within the human nasal passage across a large cohort of individuals (n = 79) comprising individuals suffering from chronic nasal inflammation clinically known as chronic rhinosinusitis (CRS) and individuals not suffering from inflammation (CRS-free). While individuals had their own unique bacterial fingerprint that was consistent across the anatomical regions, these bacterial fingerprints formed into distinct delineated groups comprising core bacterial members, which were consistent across all four swabbed anatomical regions irrespective of health status. The most significant observed pattern was the difference between the global bacterial profiles of swabbed and tissue biopsy samples from the same individuals, being also consistent across different anatomical regions. Importantly, no statistically significant differences could be observed concerning the global bacterial communities, any of the bacterial species or the range of diversity indices used to compare between CRS and CRS-free individuals, and between two CRS phenotypes (without nasal polyps and with nasal polyps). Thus, the role of bacteria in the pathogenesis of sinusitis remains uncertain.Citation
Exploring the bacterial assemblages along the human nasal passage. 2016, 18 (7):2259-71 Environ. Microbiol.Affiliation
Helmholtz Centre for infection research, Inhoffenstr. 7,38124 Braunschweig, Germany.Journal
Environmental microbiologyPubMed ID
27207744Type
ArticleLanguage
enISSN
1462-2920ae974a485f413a2113503eed53cd6c53
10.1111/1462-2920.13378
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/