A novel protein quality control mechanism contributes to heat shock resistance of worldwide-distributed Pseudomonas aeruginosa clone C strains.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Hasni, Muhammad Sharif
MetadataShow full item record
AbstractPseudomonas aeruginosa is a highly successful nosocomial pathogen capable of causing a wide variety of infections with clone C strains most prevalent worldwide. In this study, we initially characterize a molecular mechanism of survival unique to clone C strains. We identified a P. aeruginosa clone C-specific genomic island (PACGI-1) that contains the highly expressed small heat shock protein sHsp20c, the founding member of a novel subclass of class B bacterial small heat shock proteins. sHsp20c and adjacent gene products are involved in resistance against heat shock. Heat stable sHsp20c is unconventionally expressed in stationary phase in a wide temperature range from 20 to 42°C. Purified sHsp20c has characteristic features of small heat shock protein class B as it is monodisperse, forms sphere-like 24-meric oligomers and exhibits significant chaperone activity. As the P. aeruginosa clone C population is significantly more heat shock resistant than genetically unrelated P. aeruginosa strains without sHsp20c, the horizontally acquired shsp20c operon might contribute to the survival of worldwide-distributed clone C strains.
CitationA novel protein quality control mechanism contributes to heat shock resistance of worldwide-distributed Pseudomonas aeruginosa clone C strains. 2015, 17 (11):4511-26 Environ. Microbiol.
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7,38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- In silico comparison of pKLC102-like genomic islands of Pseudomonas aeruginosa.
- Authors: Würdemann D, Tümmler B
- Issue date: 2007 Oct
- Cloning and sequencing of the genes coding for the 10- and 60-kDa heat shock proteins from Pseudomonas aeruginosa and mapping of a species-specific epitope.
- Authors: Sipos A, Klocke M, Frosch M
- Issue date: 1991 Sep
- Two FtsH Proteases Contribute to Fitness and Adaptation of <i>Pseudomonas aeruginosa</i> Clone C Strains.
- Authors: Kamal SM, Rybtke ML, Nimtz M, Sperlein S, Giske C, Trček J, Deschamps J, Briandet R, Dini L, Jänsch L, Tolker-Nielsen T, Lee C, Römling U
- Issue date: 2019
- Molecular evolution of metallo-beta-lactamase-producing Pseudomonas aeruginosa in a nosocomial setting of high-level endemicity.
- Authors: Lagatolla C, Edalucci E, Dolzani L, Riccio ML, De Luca F, Medessi E, Rossolini GM, Tonin EA
- Issue date: 2006 Jul
- Diversity of the abundant pKLC102/PAGI-2 family of genomic islands in Pseudomonas aeruginosa.
- Authors: Klockgether J, Würdemann D, Reva O, Wiehlmann L, Tümmler B
- Issue date: 2007 Mar