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dc.contributor.authorAndzinski, Lisa
dc.contributor.authorSpanier, Julia
dc.contributor.authorKasnitz, Nadine
dc.contributor.authorKröger, Andrea
dc.contributor.authorJin, Lei
dc.contributor.authorBrinkmann, Melanie M
dc.contributor.authorKalinke, Ulrich
dc.contributor.authorWeiss, Siegfried
dc.contributor.authorJablonska, Jadwiga
dc.contributor.authorLienenklaus, Stefan
dc.date.accessioned2016-09-07T09:33:33Z
dc.date.available2016-09-07T09:33:33Z
dc.date.issued2016-09-15
dc.identifier.citationGrowing tumors induce a local STING dependent Type I IFN response in dendritic cells. 2016, 139 (6):1350-7 Int. J. Canceren
dc.identifier.issn1097-0215
dc.identifier.pmid27116225
dc.identifier.doi10.1002/ijc.30159
dc.identifier.urihttp://hdl.handle.net/10033/619939
dc.description.abstractThe importance of endogenous Type I IFNs in cancer immune surveillance is well established by now. Their role in polarization of tumor-associated neutrophilic granulocytes into anti-tumor effector cells has been recently demonstrated. Yet, the cellular source of Type I IFNs as well as the mode of induction is not clearly defined. Here, we demonstrate that IFN-β is induced by growing murine tumors. Induction is mainly mediated via STING-dependent signaling pathways, suggesting tumor derived DNA as trigger. Transcription factors IRF3 and IRF5 were activated under these conditions which is consistent with tumor infiltrating dendritic cells (DCs) being the major cellular source of IFN-β at the tumor site. Besides DCs, tumor cells themselves are induced to contribute to the production of IFN-β. Taken together, our data provide further information on immune surveillance by Type I IFNs and suggest novel potent cellular targets for future cancer therapy.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleGrowing tumors induce a local STING dependent Type I IFN response in dendritic cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalInternational journal of canceren
refterms.dateFOA2017-09-15T00:00:00Z
html.description.abstractThe importance of endogenous Type I IFNs in cancer immune surveillance is well established by now. Their role in polarization of tumor-associated neutrophilic granulocytes into anti-tumor effector cells has been recently demonstrated. Yet, the cellular source of Type I IFNs as well as the mode of induction is not clearly defined. Here, we demonstrate that IFN-β is induced by growing murine tumors. Induction is mainly mediated via STING-dependent signaling pathways, suggesting tumor derived DNA as trigger. Transcription factors IRF3 and IRF5 were activated under these conditions which is consistent with tumor infiltrating dendritic cells (DCs) being the major cellular source of IFN-β at the tumor site. Besides DCs, tumor cells themselves are induced to contribute to the production of IFN-β. Taken together, our data provide further information on immune surveillance by Type I IFNs and suggest novel potent cellular targets for future cancer therapy.


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