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dc.contributor.authorLüdtke, Anja
dc.contributor.authorRuibal, Paula
dc.contributor.authorBecker-Ziaja, Beate
dc.contributor.authorRottstegge, Monika
dc.contributor.authorWozniak, David M
dc.contributor.authorCabeza-Cabrerizo, Mar
dc.contributor.authorThorenz, Anja
dc.contributor.authorWeller, Romy
dc.contributor.authorKerber, Romy
dc.contributor.authorIdoyaga, Juliana
dc.contributor.authorMagassouba, N'Faly
dc.contributor.authorGabriel, Martin
dc.contributor.authorGünther, Stephan
dc.contributor.authorOestereich, Lisa
dc.contributor.authorMuñoz-Fontela, César
dc.date.accessioned2016-10-12T13:56:47Z
dc.date.available2016-10-12T13:56:47Z
dc.date.issued2016-10-15
dc.identifier.citationEbola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes. 2016, 214 (suppl 3):S275-S280 J. Infect. Dis.en
dc.identifier.issn1537-6613
dc.identifier.pmid27521367
dc.identifier.doi10.1093/infdis/jiw260
dc.identifier.urihttp://hdl.handle.net/10033/620549
dc.description.abstractA number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16(+) monocytes with a poor activation profile. In survivors, CD16(+) monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology.
dc.languageENG
dc.relation'info:eu-repo/grantAgreement/EC/FP7/'.Example: info:eu-repo/grantAgreement/EC/H2020/666100en
dc.rightsopenAccessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleEbola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.
dc.typeArticleen
dc.contributor.departmentTwinCore, Centre for experimental and clinical infection research GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en
dc.identifier.journalThe Journal of infectious diseasesen
refterms.dateFOA2018-06-13T09:15:21Z
html.description.abstractA number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16(+) monocytes with a poor activation profile. In survivors, CD16(+) monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology.


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