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Authors
Ruibal, PaulaOestereich, Lisa
Lüdtke, Anja
Becker-Ziaja, Beate
Wozniak, David M
Kerber, Romy
Korva, Miša
Cabeza-Cabrerizo, Mar
Bore, Joseph A
Koundouno, Fara Raymond
Duraffour, Sophie
Weller, Romy
Thorenz, Anja
Cimini, Eleonora
Viola, Domenico
Agrati, Chiara
Repits, Johanna
Afrough, Babak
Cowley, Lauren A
Ngabo, Didier
Hinzmann, Julia
Mertens, Marc
Vitoriano, Inês
Logue, Christopher H
Boettcher, Jan Peter
Pallasch, Elisa
Sachse, Andreas
Bah, Amadou
Nitzsche, Katja
Kuisma, Eeva
Michel, Janine
Holm, Tobias
Zekeng, Elsa-Gayle
García-Dorival, Isabel
Wölfel, Roman
Stoecker, Kilian
Fleischmann, Erna
Strecker, Thomas
Di Caro, Antonino
Avšič-Županc, Tatjana
Kurth, Andreas
Meschi, Silvia
Mély, Stephane
Newman, Edmund
Bocquin, Anne
Kis, Zoltan
Kelterbaum, Anne
Molkenthin, Peter
Carletti, Fabrizio
Portmann, Jasmine
Wolff, Svenja
Castilletti, Concetta
Schudt, Gordian
Fizet, Alexandra
Ottowell, Lisa J
Herker, Eva
Jacobs, Thomas
Kretschmer, Birte
Severi, Ettore
Ouedraogo, Nobila
Lago, Mar
Negredo, Anabel
Franco, Leticia
Anda, Pedro
Schmiedel, Stefan
Kreuels, Benno
Wichmann, Dominic
Addo, Marylyn M
Lohse, Ansgar W
De Clerck, Hilde
Nanclares, Carolina
Jonckheere, Sylvie
Van Herp, Michel
Sprecher, Armand
Xiaojiang, Gao
Carrington, Mary
Miranda, Osvaldo
Castro, Carlos M
Gabriel, Martin
Drury, Patrick
Formenty, Pierre
Diallo, Boubacar
Koivogui, Lamine
Magassouba, N'Faly
Carroll, Miles W
Günther, Stephan
Muñoz-Fontela, César
Issue Date
2016-05-05
Metadata
Show full item recordAbstract
Despite the magnitude of the Ebola virus disease (EVD) outbreak in West Africa, there is still a fundamental lack of knowledge about the pathophysiology of EVD. In particular, very little is known about human immune responses to Ebola virus. Here we evaluate the physiology of the human T cell immune response in EVD patients at the time of admission to the Ebola Treatment Center in Guinea, and longitudinally until discharge or death. Through the use of multiparametric flow cytometry established by the European Mobile Laboratory in the field, we identify an immune signature that is unique in EVD fatalities. Fatal EVD was characterized by a high percentage of CD4(+) and CD8(+) T cells expressing the inhibitory molecules CTLA-4 and PD-1, which correlated with elevated inflammatory markers and high virus load. Conversely, surviving individuals showed significantly lower expression of CTLA-4 and PD-1 as well as lower inflammation, despite comparable overall T cell activation. Concomitant with virus clearance, survivors mounted a robust Ebola-virus-specific T cell response. Our findings suggest that dysregulation of the T cell response is a key component of EVD pathophysiology.Citation
Unique human immune signature of Ebola virus disease in Guinea. 2016, 533 (7601):100-4 NatureAffiliation
TWINCORE, Centre for experimental and clinical infection research GmbH, Feodor-Lynen Str. 7, 30625 Hannover, Germany.Journal
NaturePubMed ID
27147028Type
ArticleISSN
0028-0836ae974a485f413a2113503eed53cd6c53
10.1038/nature17949
Scopus Count
The following license files are associated with this item:
- Creative Commons
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