• NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.

      Simma, Narasimhulu; Bose, Tanima; Kahlfuss, Sascha; Mankiewicz, Judith; Lowinus, Theresa; Lühder, Fred; Schüler, Thomas; Schraven, Burkhart; Heine, Martin; Bommhardt, Ursula; et al. (2014)
      B cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation of B-cell function could be an effective regimen in therapeutic strategies. Since the non-competitive NMDAR antagonist memantine is clinically applied to treat advanced Alzheimer`s disease and ketamine is supposed to improve the course of resistant depression, it is important to know how these drugs affect B-cell function.