Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.

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Authors
Lindqvist, Richard
Mundt, Filip
Gilthorpe, Jonathan D
Wölfel, Silke
Gekara, Nelson O
Kröger, Andrea
Överby, Anna K
Issue Date
2016-10-24

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Abstract
Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined.
Citation
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. 2016, 13 (1):277 J Neuroinflammation
Affiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Journal
Journal of neuroinflammation
URI
http://hdl.handle.net/10033/620609
DOI
10.1186/s12974-016-0748-7
PubMed ID
27776548
Type
Article
ISSN
1742-2094
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The following license files are associated with this item:

http://creativecommons.org/licenses/by-nc-sa/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/