Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.

Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D; Wölfel, Silke; Gekara, Nelson O; Kröger, Andrea; Överby, Anna K

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Authors

Lindqvist, Richard
Mundt, Filip
Gilthorpe, Jonathan D
Wölfel, Silke
Gekara, Nelson O
Kröger, Andrea
Överby, Anna K

Issue Date

2016-10-24

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Abstract

Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined.

Citation

Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. 2016, 13 (1):277 J Neuroinflammation

Affiliation

Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.

Type

Article

ISSN

1742-2094

Collections

publications of the research group intravital microscopy in infection and immunity (INMI)

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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/